反应条件
1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / diethyl ether; hexane / 0.75 h / -78 °C / Inert atmosphere 1.2: -78 - 20 °C / Inert atmosphere 2.1: ammonia / tetrahydrofuran; water / 12 h / 130 °C / Parr reactor View Scheme
参考文献
Trabanco, Andres A.; Tresadern, Gary; MacDonald, Gregor J.; Vega, Juan Antonio; De Lucas, Ana Isabel; Matesanz, Encarnacion; Garcia, Aranzazu; Linares, Maria Lourdes; Alonso De Diego, Sergio A.; Alonso, Jose Manuel; Oehlrich, Daniel; Ahnaou, Abdelah; Drinkenburg, Wilhelmus; MacKie, Claire; Andres, Jose Ignacio; Lavreysen, Hilde; Cid, Jose Maria
Journal of Medicinal Chemistry, 2012 , vol. 55, # 6 p. 2688 - 2701