1-(苄氧基)-3-(氯甲基)苯合成路线 （共 14 条）
反应条件
thionyl chloride in dichloromethane T=0°C; 3 h;
参考文献
Lee, Jeewoo; Lee, Ju-Hyun; Kim, Su Yeon; Perry, Nicholas A.; Lewin, Nancy E.; Ayres, Jolene A.; Blumberg, Peter M.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 2022 - 2031
反应条件
1: With triethylamine in dichloromethane T=0 - 20°C; 2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP1782811 A1, 2007 ;
Location in patent: Page/Page column 67 ;
反应条件
1: 95 percent / potassium carbonate / acetone / 4 h / Heating 2: 94 percent / thionyl chloride / CH2Cl2 / 3 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 6 p. 2022 - 2031
反应条件
1: 85 percent / benzyltrimethylammonium hydroxide, K2CO3 / methanol; dimethylformamide / 18 h / 70 °C 2: SOCl2 / CH2Cl2 / 0.5 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 3 p. 606 - 612
反应条件
1: 95 percent / potassium carbonate / acetone / 4 h / Heating 2: 94 percent / thionyl chloride / CH2Cl2 / 3 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 6 p. 2022 - 2031
反应条件
1: NaBH4 / methanol / 20 °C 2: SOCl2 / dioxane / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 16 p. 2205 - 2208
反应条件
1: K2CO3 / methanol / Heating 2: NaBH4 / methanol / 20 °C 3: SOCl2 / dioxane / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 16 p. 2205 - 2208
反应条件
sodium in water; potassium carbonate; acetone
参考文献
Pfizer Inc.
Patent: US4306097 A1, 1981 ;
反应条件
1: 1.) solid KOH 2.) 1N HCl / 1.) tetrabutylammonium bromide / 1.) CH2Cl2, 0 to 15 deg C 2.) ether, 0 deg C. 2: 1.) hydrogen 2.) 6N HCl / 1.) 10 percent Pd/C / 1.) ethanol View Scheme
参考文献
O'Donnell, Martin J.; LeClef, Brigitte; Rusterholz, David B.; Ghosez, Leon; Antoine, Jean-Pierre; Navarro, Mirtha
Tetrahedron Letters, 1982 , vol. 23, # 41 p. 4259 - 4262
反应条件
sodium hydroxide; tetracarbonylcobaltate(1-) ion in methanol T=55°C; 4 h;
参考文献
Rao, B. Nageswara; Adapa, Srinivas R.; Pardhasaradhi, M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 84 - 85
