反应条件
1.1: potassium carbonate / tetrahydrofuran / 17 h / 20 °C / |Reflux; |Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.83 h / -70 - -60 °C / |Inert atmosphere
2.2: 1.25 h / -70 °C / |Inert atmosphere
3.1: acetic acid; palladium 10 on activated carbon; hydrogen / 6 h / 70 °C / 2068.65 Torr
4.1: sodium hydrogencarbonate / ethylene glycol dimethyl ether / 85 °C / |Inert atmosphere
View Scheme
参考文献
Armitage, Mark; Bret, Guillaume; Choudary, Bernie M.; Kingswood, Mike; Loft, Mike; Moore, Steve; Smith, Steve; Urquhart, Michael W. J.
Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1626 - 1634
