6-溴-2H-1,4-苯并噁嗪-3(4H)-酮合成路线 （共 20 条）
反应条件
sodium hydrogencarbonate in water; isobutyl methylketone T=0°C; Reflux;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 18, # 3 p. 1288 - 1296
反应条件
iron; acetic acid T=50°C; 6 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 15, # 17 p. 5912 - 5949
反应条件
iron; acetic acid in ethanol T=20°C; Heating / reflux;
参考文献
WO2008/150848 A1, ;
Page/Page column 134-135 ;
WO 2008/150848 A1
反应条件
in potassium hydroxide
参考文献
Indian Journal of Chemistry, , vol. 7, p. 658 - 661
反应条件
bromine; acetic acid 1 h; cooling;
参考文献
Journal of Chemical Research, Miniprint, , # 11 p. 1120 - 1128
反应条件
1: bromine; acetic acid / 3 h / 20 - 24 °C 2: hydrogenchloride; water / ethanol / 4 h / |Reflux 3: sodium hydrogencarbonate / tetrahydrofuran / 0.67 h / 5 - 8 °C / |Inert atmosphere 4: potassium carbonate / tetrahydrofuran / 17 h / 20 °C / |Reflux; |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 10 p. 1626 - 1634
反应条件
1: hydrogenchloride; water / ethanol / 4 h / |Reflux 2: sodium hydrogencarbonate / tetrahydrofuran / 0.67 h / 5 - 8 °C / |Inert atmosphere 3: potassium carbonate / tetrahydrofuran / 17 h / 20 °C / |Reflux; |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 10 p. 1626 - 1634
反应条件
1: sodium hydrogencarbonate / tetrahydrofuran / 0.67 h / 5 - 8 °C / |Inert atmosphere 2: potassium carbonate / tetrahydrofuran / 17 h / 20 °C / |Reflux; |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 10 p. 1626 - 1634
反应条件
caesium carbonate in N,N-dimethyl-formamide
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5432 - 5435
