6-溴-2H-1,4-苯并噁嗪-3(4H)-酮合成路线 （共 20 条）
参考文献
US2004/92512 A1, ;
Page 28 ;
US 20040092512 A1
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride T=100°C; 16 h; Inert atmosphere;
参考文献
WO2010/116282 A1, ;
Page/Page column 55-56 ;
WO 2010/116282 A1
反应条件
bromine; acetic acid T=50°C; 1 h;
参考文献
Hanson, James R.; Richards, Lisa; Rozas, Panteleimon
Journal of Chemical Research, Miniprint, 2003 , # 11 p. 1120 - 1128
反应条件
potassium hydroxide in acetone
参考文献
Incyte Corporation; Zhuo, Jincong; Xu, Meizhong; Qian, Ding-Quan
Patent: US2014/171405 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
1: With borane-THF in tetrahydrofuran T=20°C; 1.16667 h; Heating / reflux; 2: With sodium hydroxide; water in tetrahydrofuran
参考文献
WO2008/44022 A1, ;
Page/Page column 29 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=80°C;
参考文献
ALANTOS PHARMACEUTICALS HOLDING, INC.
Patent: WO2008/63671 A2, 2008 ;
Location in patent: Page/Page column 174 ;
WO 2008/063671 A2
反应条件
in 1-methyl-pyrrolidin-2-one T=200°C; 4 h; Inert atmosphereMicrowave irradiation;
参考文献
AQUILUS PHARMACEUTICALS, INC.; SUCHOLEIKI, Irving
Patent: WO2014/62204 A1, 2014 ;
Location in patent: Page/Page column 33 ;
反应条件
1: water; N,N-dimethyl-formamide View Scheme
参考文献
Incyte Corporation; Zhuo, Jincong; Xu, Meizhong; Qian, Ding-Quan
Patent: US2014/171405 A1, 2014 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.83 h / -70 - -60 °C / |Inert atmosphere
1.2: 1.25 h / -70 °C / |Inert atmosphere
2.1: acetic acid; palladium 10 on activated carbon; hydrogen / 6 h / 70 °C / 2068.65 Torr
3.1: sodium hydrogencarbonate / ethylene glycol dimethyl ether / 85 °C / |Inert atmosphere
View Scheme
参考文献
Armitage, Mark; Bret, Guillaume; Choudary, Bernie M.; Kingswood, Mike; Loft, Mike; Moore, Steve; Smith, Steve; Urquhart, Michael W. J.
Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1626 - 1634
反应条件
(i) aq. NaOH, (ii) /BRN= 607485/, aq. NaOH; Multistep reaction;
参考文献
Drain; Daly; Davy; Horlington; Howes; Scruton; Selway
The Journal of pharmacy and pharmacology, 1970 , vol. 22, # 9 p. 684 - 693
