5,6-二甲氧基-1,2,3,4-四氢1-萘酮合成路线 （共 26 条）
反应条件
polyphosphoric acid
T=60°C; Inert atmosphere;
参考文献
Bonner, Lisa A.; Chemel, Benjamin R.; Watts, Val J.; Nichols, David E.
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 18 p. 6763 - 6770
反应条件
1: With sulfuric acid
T=85 - 90°C; 0.25 h;
2: With potassium carbonate; dimethyl sulfate in acetone
2 h; Reflux;
参考文献
Lahiri, Saswata; Ramarao; Rao, B. Venkateswara; Rao, A.V. Rama; Chorghade, Mukund S.
Organic Process Research and Development, 1999 , vol. 3, # 1 p. 71 - 72
反应条件
boron trifluoride diethyl etherate; mercury(II) oxide in tetrahydrofuran; water
参考文献
Rigby, James H.; Kotnis, Atul; Kramer, James
Tetrahedron Letters, 1983 , vol. 24, # 29 p. 2939 - 2940
反应条件
1: 57.6 g / H2 / 5percent Pd/C / acetic acid
2: PCl4, SnCl4
View Scheme
参考文献
Beetz, Tom; Meuleman, Dick G.; Wieringa, Joop H.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 714 - 719
反应条件
1: NaH, Me2SO / tetrahydrofuran / 5 h / 5 °C
2: 57.6 g / H2 / 5percent Pd/C / acetic acid
3: PCl4, SnCl4
View Scheme
参考文献
Beetz, Tom; Meuleman, Dick G.; Wieringa, Joop H.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 714 - 719
反应条件
1: piperidine / pyridine / 50 °C
2: H2, AcOH / Pd/C / ethanol / Ambient temperature
3: PPA / 80 °C
View Scheme
参考文献
Cooper, Christopher B.; Blair, Kyle T.; Jones, Christopher S.; Minich, Martha L.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1747 - 1752
反应条件
1: 56 percent / p-toluenesulfonic acid / acetonitrile / 24 h / 0 °C
2: 55 percent / HgO, aq. THF / BF3.Et2O
View Scheme
参考文献
Rigby, James H.; Kotnis, Atul; Kramer, James
Tetrahedron Letters, 1983 , vol. 24, # 29 p. 2939 - 2940
反应条件
1: H2, AcOH / Pd/C / ethanol / Ambient temperature
2: PPA / 80 °C
View Scheme
参考文献
Cooper, Christopher B.; Blair, Kyle T.; Jones, Christopher S.; Minich, Martha L.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1747 - 1752
反应条件
1: 85 percent / PPh3, CCl4 / Heating
2: 1.) Bu3N, Pd(OAc)2, 2.) H2 / 2.) 10percent Pd/C / 1.) 100 deg C, 2.) MeOH, 50 psi
3: 6 N aq. KOH / ethanol / 2 h / Heating
4: polyphosphoric ester / CHCl3 / Ambient temperature
View Scheme
参考文献
Kumar, Punit
Organic Preparations and Procedures International, 1997 , vol. 29, # 4 p. 477 - 480
反应条件
1: 1.) Bu3N, Pd(OAc)2, 2.) H2 / 2.) 10percent Pd/C / 1.) 100 deg C, 2.) MeOH, 50 psi
2: 6 N aq. KOH / ethanol / 2 h / Heating
3: polyphosphoric ester / CHCl3 / Ambient temperature
View Scheme
参考文献
Kumar, Punit
Organic Preparations and Procedures International, 1997 , vol. 29, # 4 p. 477 - 480
