N-叔丁氧羰基-1-氧杂-8-氮杂螺[4.5]癸烷-3-醇合成路线 （共 6 条）
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; 1 h; 2: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; water T=0 - 20°C; 18 h;
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2004/78750 A1, 2004 ;
Location in patent: Page 88-89 ;
WO 2004/078750 A1
反应条件
1: With sodium periodate in water; tert-butyl alcohol T=50°C; 0.5 h; Industry scale; 2: With sodium disulfite in water; tert-butyl alcohol T=20 - 50°C; 59 h; Industry scale;
参考文献
PFIZER INC.; LONG, Scott Allen; MEYERS, Marvin Jay; PELC, Matthew James; SCHWEITZER, Barbara Ann; THORARENSEN, Atli; WANG, Lijuan Jane
Patent: WO2010/58318 A1, 2010 ;
Location in patent: Page/Page column 26 ;
WO 2010/058318 A1
反应条件
palladium monocarbide in tetrahydrofuran
反应条件
sodium tetrahydroborate in methanol T=0°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 21 p. 6545 - 6553
反应条件
pyridine-SO3 complex; triethylamine in dimethyl sulfoxide T=0 - 20°C;
参考文献
PFIZER INC.; LONG, Scott Allen; MEYERS, Marvin Jay; PELC, Matthew James; SCHWEITZER, Barbara Ann; THORARENSEN, Atli; WANG, Lijuan Jane
Patent: WO2010/58318 A1, 2010 ;
Location in patent: Page/Page column 26-27 ;
WO 2010/058318 A1
反应条件
1: With carbon tetrabromide in dichloromethane
0.166667 h;
2: With triphenylphosphine in dichloromethane
T=-5 - 20°C;
参考文献
PFIZER INC.; LONG, Scott Allen; MEYERS, Marvin Jay; PELC, Matthew James; SCHWEITZER, Barbara Ann; THORARENSEN, Atli; WANG, Lijuan Jane
Patent: WO2010/58318 A1, 2010 ;
Location in patent: Page/Page column 26 ;
WO 2010/058318 A1
