3-溴-1,8-萘二甲酸酐合成路线 （共 13 条）
反应条件
sulfuric acid; bromine; silver sulphate T=65°C; 6 h;
参考文献
Pinto-Bazurco Mendieta, Mariano A.E.; Negri, Matthias; Jagusch, Carsten; Hille, Ulrike E.; Mueller-Vieira, Ursula; Schmidt, Dirk; Hansen, Klaus; Hartmann, Rolf W.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 267 - 273
反应条件
1: With sulfuric acid T=20 - 25°C; 0.5 h; Inert atmosphere; 2: With 1,3-dibromo-5,5-dimethyl-hydantoin T=-10 - 20°C; 1 h; Inert atmosphere;
参考文献
Kuethe, Jeffrey T.; Childers, Karla G.; Humphrey, Guy R.; Journet, Michel; Peng, Zhihui
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1201 - 1208
反应条件
1: With mercury(II) diacetate; sodium hydroxide in water T=60 - 98°C; 36 h; 2: With hydrogenchloride in water T=96 - 98°C; 5 h;
参考文献
TAKEDA GMBH; HOFFMEYER, Angelika; BOER, Rainer; HEßMANN, Manuela; PAHL, Andreas; DUNKERN, Torsten; HARTUNG, Simone; ZITT, Christof; VOLZ, Jürgen; PRÄCHTER, Christiane; MAKHIJA, Mahindra; JAIN, Hiteshkumar; GAVADE, Sandip; PRABHU, Arati; TIWARI, Manojkumar; KECHE, Ashish; PATEL, Sarvesh
Patent: WO2013/164326 A1, 2013 ;
Location in patent: Page/Page column 19; 20 ;
反应条件
sodium hydroxide; acetic acid; mercury(II) oxide 96 h; Heating;
参考文献
Pinto-Bazurco Mendieta, Mariano A.E.; Negri, Matthias; Jagusch, Carsten; Hille, Ulrike E.; Mueller-Vieira, Ursula; Schmidt, Dirk; Hansen, Klaus; Hartmann, Rolf W.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 267 - 273
反应条件
1: With mercury(II) oxide; sodium hydroxide in water; acetic acid 96 h; Inert atmosphereReflux; 2: With hydrogenchloride in water; acetic acid 4 h; Inert atmosphereReflux;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; CHOREV, Michael; AKTAS, Bertal Huseyin; HALPERIN, Jose A.; WAGNER, Gerhard
Patent: WO2012/6068 A2, 2012 ;
Location in patent: Page/Page column 70-71 ;
反应条件
1: With mercury(II) diacetate; sodium hydroxide in water T=60 - 98°C; 36 h; 2: With hydrogenchloride in water T=96 - 98°C; 5 h;
参考文献
TAKEDA GMBH; HOFFMEYER, Angelika; BOER, Rainer; HEßMANN, Manuela; PAHL, Andreas; DUNKERN, Torsten; HARTUNG, Simone; ZITT, Christof; VOLZ, Jürgen; PRÄCHTER, Christiane; MAKHIJA, Mahindra; JAIN, Hiteshkumar; GAVADE, Sandip; PRABHU, Arati; TIWARI, Manojkumar; KECHE, Ashish; PATEL, Sarvesh
Patent: WO2013/164326 A1, 2013 ;
Location in patent: Page/Page column 19; 20 ;
反应条件
Multistep reaction. Title compound not separated from byproducts;
参考文献
Moseley, Jonathan D.; Moss, William O.; Welham, Matthew J.; Ancell, Claire L.; Banister, John; Bowden, Sharon A.; Norton, Glenn; Young, Maureen J.
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 58 - 66
反应条件
1: ethanol / 2 h / Reflux
2: potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / toluene / 28 h / Reflux; Inert atmosphere
View Scheme
参考文献
Xie, Lijuan; Cui, Jingnan; Qian, Xuhong; Xu, Yufang; Liu, Jianwen; Xu, Ruian
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 2 p. 961 - 967
反应条件
1: 1.) yellow mercuric oxide; 2.) hydchloric acid / 1.) aq. acetic acid; 2.) water
2: 100 percent / LiAlH4 / diethyl ether / 1.) reflux, 3 h; 2.) room temperature, 14 h
View Scheme
参考文献
MERCK FROSST CANADA LTD.; CHIH-YU CHEN, Austin; LALIBERTE, Sebastien; LAROUCHE, Guillaume; HAN, Yongxin; MCKAY, Daniel
Patent: WO2011/20193 A1, 2011 ;
WO 2011/020193 A1
反应条件
1: 1.) yellow mercuric oxide; 2.) hydchloric acid / 1.) aq. acetic acid; 2.) water
2: 100 percent / LiAlH4 / diethyl ether / 1.) reflux, 3 h; 2.) room temperature, 14 h
3: 51 percent
View Scheme
参考文献
Dixon, Elisabeth A.; Fischer, Alfred; Robinson, Frank P.
Canadian Journal of Chemistry, 1981 , vol. 59, p. 2629 - 2641
