2-氯-6-硝基苯并噻唑合成路线 （共 33 条）
反应条件
sulfuric acid; nitric acid T=0 - 25°C; 3 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 14 p. 3328 - 3332
反应条件
1: With phosphoric acid; sodium nitrite in water T=0°C; 1.5 h; 2: With copper(II) sulfate; sodium chloride in water T=0°C; 0.5 h;
参考文献
US2007/281945 A1, ;
Page/Page column 15 ;
US 20070281945 A1
反应条件
sulfuric acid; nitric acid in water T=0 - 5°C; 3.33333 h;
参考文献
WO2004/37251 A1, ;
Page/Page column 99; 100 ;
反应条件
sulfuric acid; nitric acid T=0°C; 1 h;
参考文献
WO2007/121154 A2, ;
Page/Page column 38 ;
WO 2007/121154 A2
反应条件
thionyl chloride T=50°C; 2 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 14 p. 4022 - 4025
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 74, # 8 p. 3229 - 3231
反应条件
1: 32 percent / Br2; AcOH / 1 h / cooling 2: 85 percent / NH2NH2*H2O; NH2NH2*H2SO4 / ethane-1,2-diol / 2 h / 120 °C 3: 93 percent / SOCl2 / 2 h / 50 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 14 p. 4022 - 4025
反应条件
1: concentrated H2SO4; HNO3 2: PCl5; POCl3 View Scheme
参考文献
Yakugaku Zasshi, , vol. 66, p. Ausg. B, S. 75
Chem.Abstr., , p. 112
参考文献
Ukrainskii Khimicheskii Zhurnal (Russian Edition), , vol. 16, p. 394,398
Chem.Abstr., , p. 11393
反应条件
1.1: nitric acid / 1 h / -5 - 0 °C 2.1: hydrogenchloride; phosphoric acid; sodium nitrite / -10 - 0 °C 2.2: 3 h / 20 °C View Scheme
参考文献
Chinese Chemical Letters, , vol. 21, # 5 p. 554 - 557
