3-甲基-4-硝基苯甲酸甲酯合成路线 （共 34 条）
反应条件
1: 92.1 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 2: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C 3: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C 4: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C View Scheme
参考文献
Yang, Ling-Chun; Qi, Chuan-Min; Zhang, Guan-Xin; Zou, Nan-Zhi
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1107 - 1112
反应条件
1: in ethanol 2: With NH2NH2•xH2O in water T=90°C; 48 h;
参考文献
ARES TRADING S.A.; QUATTROPANI, Anna; SWINNEN, Dominique
Patent: WO2013/182274 A1, 2013 ;
Location in patent: Page/Page column 47; 48 ;
反应条件
1: 55 percent / dibenzoyl peroxide, NBS / CCl4 / 22.5 h / 90 °C / Irradiation 2: 95 percent / CHCl3 / 1 h / Heating 3: 99 percent / Et3N / CH2Cl2 / Ambient temperature 4: 47 percent / PPh3, CO / Pd(OAc)2 / acetonitrile / 120 h / 3040 Torr / Heating View Scheme
参考文献
Kamiya; Matsui; Shirahase; Nakamura; Wada; Kanda; Shimaji; Kakeya
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 10 p. 1692 - 1695
反应条件
TiCl3 1.) DMF, reflux, 13 h; 2.) MeOH, r.t., 7 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Somei, Masanori; Saida, Yoshihiro; Komura, Naoko
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 10 p. 4116 - 4125
反应条件
1: 2.) titanium(III) chloride / 1.) DMF, reflux, 13 h; 2.) MeOH, r.t., 7 min 2: 82 percent / LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Somei, Masanori; Saida, Yoshihiro; Komura, Naoko
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 10 p. 4116 - 4125
反应条件
1.1: palladium 10 on activated carbon; ammonium formate / methanol / 3 h / 20 °C / |Inert atmosphere 2.1: potassium acetate / toluene / 0.17 h / |Inert atmosphere; |Reflux 2.2: 16.5 h / |Reflux; |Inert atmosphere 3.1: lithium hydroxide hydrate / tetrahydrofuran; water / 48 h / |Reflux 3.2: pH 4 View Scheme
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
反应条件
1: 2.) titanium(III) chloride / 1.) DMF, reflux, 13 h; 2.) MeOH, r.t., 7 min 2: 82 percent / LiAlH4 / tetrahydrofuran / 3 h / Heating 3: 91.7 percent / MnO2 / CH2Cl2 / 113 h / Ambient temperature View Scheme
参考文献
Somei, Masanori; Saida, Yoshihiro; Komura, Naoko
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 10 p. 4116 - 4125
反应条件
1: 92.1 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 2: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C 3: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C 4: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 5: 90 percent / acetic acid / 2 h / Heating View Scheme
参考文献
Yang, Ling-Chun; Qi, Chuan-Min; Zhang, Guan-Xin; Zou, Nan-Zhi
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1107 - 1112
反应条件
hydrazine hydrate; nickel in methanol T=20°C;
参考文献
Yang, Ling-Chun; Qi, Chuan-Min; Zhang, Guan-Xin; Zou, Nan-Zhi
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1107 - 1112
反应条件
1: 92.1 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 2: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Yang, Ling-Chun; Qi, Chuan-Min; Zhang, Guan-Xin; Zou, Nan-Zhi
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1107 - 1112
