3-甲基-4-硝基苯甲酸甲酯合成路线 （共 34 条）
反应条件
1: 92.1 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 2: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C 3: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C View Scheme
参考文献
Yang, Ling-Chun; Qi, Chuan-Min; Zhang, Guan-Xin; Zou, Nan-Zhi
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1107 - 1112
反应条件
1: 92.1 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 2: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C 3: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C 4: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 5: 90 percent / acetic acid / 2 h / Heating 6: 82.3 percent / NaOH; water / methanol / 2 h / Heating View Scheme
参考文献
Yang, Ling-Chun; Qi, Chuan-Min; Zhang, Guan-Xin; Zou, Nan-Zhi
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1107 - 1112
反应条件
1: ammonium chloride; iron / methanol; water / 4 h / |Reflux 2: sodium nitrite; tetrafluoroboric acid / water / 0.25 h / 0 - 20 °C 3: potassium acetate; 18-crown-6 ether / chloroform / 24 h / 20 °C 4: water; sodium hydroxide / methanol / 1 h / |Reflux 5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0 - 20 °C 6: tetrahydrofuran / 2 h / 0 °C View Scheme
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
反应条件
1: 92.1 percent / aq. hydrazine / Raney Ni / methanol / 20 °C
2: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C
3: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C
4: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C
5: 90 percent / acetic acid / 2 h / Heating
6: 82.3 percent / NaOH; water / methanol / 2 h / Heating
7: 67.1 percent / polyphosphoric acid / 20 h / 160 °C
View Scheme
参考文献
Yang, Ling-Chun; Qi, Chuan-Min; Zhang, Guan-Xin; Zou, Nan-Zhi
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1107 - 1112
反应条件
1: 67 percent / NBS, benzoylperoxide / CCl4 / 5 h / Heating; Irradiation
2: 64 percent / 0.2 N NaOH / methanol / 0.25 h / Heating
3: 99 percent / H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr
4: 88 percent / 2,6-lutidine / benzene
5: 84 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature
6: 45 percent / water, NaOH / pyridine; methanol / 24 h / Heating
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
1: 67 percent / NBS, benzoylperoxide / CCl4 / 5 h / Heating; Irradiation
2: 64 percent / 0.2 N NaOH / methanol / 0.25 h / Heating
3: 99 percent / H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr
4: 88 percent / 2,6-lutidine / benzene
5: 84 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature
6: 45 percent / water, NaOH / pyridine; methanol / 24 h / Heating
7: 50 percent / BBr3, NaHCO3 / CH2Cl2 / 24 h / -35 °C
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
1: 67 percent / NBS, benzoylperoxide / CCl4 / 5 h / Heating; Irradiation
2: 64 percent / 0.2 N NaOH / methanol / 0.25 h / Heating
3: 99 percent / H2 / PtO2, 80percent / methanol / 20 h / 25 °C / 735.5 Torr
4: 88 percent / 2,6-lutidine / benzene
5: 84 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
N-bromosuccinmide; meta-chloroperoxybenzoic acid in tetrachloromethane
5 h; HeatingIrradiation;
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
18 h; Heating;
参考文献
Aujard, Isabelle; Benbrahim, Chouaha; Gouget, Marine; Ruel, Odile; Baudin, Jean-Bernard; Neveu, Pierre; Jullien, Ludovic
Chemistry - A European Journal, 2006 , vol. 12, # 26 p. 6865 - 6879
反应条件
1: 67 percent / NBS, benzoylperoxide / CCl4 / 5 h / Heating; Irradiation
2: 64 percent / 0.2 N NaOH / methanol / 0.25 h / Heating
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
