2,2,6-三甲基环己酮合成路线 （共 96 条）
反应条件
1: (i), (ii) Ph3SiOH, (iii) (Ph3SiO)3VO
2: CrO3, H2SO4
View Scheme
参考文献
Branca,S.J. et al.
Journal of Organic Chemistry, 1977 , vol. 42, # 19 p. 3165 - 3168
反应条件
1: sodium bisulphate / H2O / 6 h / 0 - 15 °C
2: SOCl2, pyridine / benzene / 1 h / Heating
3: 1.8548 g / benzoyl peroxide, N-bromosuccinimide / CCl4 / 0.67 h / Heating
4: 1) NaI, 2) NaBH4 / 1) DMSO, r.t., 15 min, 2) MeOH, 1.5 h
View Scheme
参考文献
Kutney, James P.; Gunning, Philip J.; Clewley, Robin G.; Somerville, John; Rettig, Steven J.
Canadian Journal of Chemistry, 1992 , vol. 70, # 7 p. 2094 - 2114
反应条件
1: (i), (ii) Ph3SiOH, (iii) (Ph3SiO)3VO
2: CrO3, H2SO4
3: oxalyl dichloride
5: Cu(acac)2
6: aq. NaOH
7: oxalyl dichloride
View Scheme
参考文献
Branca,S.J. et al.
Journal of Organic Chemistry, 1977 , vol. 42, # 19 p. 3165 - 3168
反应条件
in benzene
T=90 - 100°C; 0.5 h;
参考文献
Fitjer, Lutz; Quabeck, Ulrike
Synthetic Communications, 1985 , vol. 15, # 10 p. 855 - 864
反应条件
potassium bases
T=90 - 130°C;
参考文献
Dauben, William G.; Takasugi, James J.
Tetrahedron Letters, 1987 , vol. 28, # 38 p. 4377 - 4380
反应条件
pyridine; n-butyllithium; methyl iodide
1.) THF, hexane, -78 deg C, 30 min, 2.) -78 deg C, 2 h; -78 deg C -> 0 deg C, 3.) acetone, room temperature, 16 h; Yield given. Multistep reaction;
参考文献
Johnson,C.R.; Elliott,R.C.
Journal of the American Chemical Society, 1982 , vol. 104, p. 7041
