1: 2,6-dichloropyridin-3-ylamine With sodium hexamethyldisilazane in tetrahydrofuran T=-10°C; 1 h; 2: diamidazolt;3,4-a,3',4'-dgt;piperazino-2,5-dione in tetrahydrofuran T=20°C;

potassium carbonate in N,N-dimethyl acetamide Heating;