3-(2-甲基-1,3-二氧戊环-2-基)丙醛合成路线 （共 21 条）
反应条件
1: n-BuLi in hexane / 1) THF, 0.5 h, room temperature, 2) 3 h, room temperature 2: 87 percent / p-toluenesulphonic acid (aq.), silica gel / CH2Cl2 / 3 h View Scheme
参考文献
Joshi, N. N.; Mamdapur, V. R.; Chadha, M. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 6 p. 577 - 579
反应条件
diisobutylaluminium hydride in dichloromethane
T=-78°C;
参考文献
Wanner, Martin J.; Boots, Rowan N.A.; Eradus, Bram; De Gelder, Rene; Van Maarseveen, Jan H.; Hiemstra, Henk
Organic Letters, 2009 , vol. 11, # 12 p. 2579 - 2581
反应条件
sodium acetate; pyridinium chlorochromate in dichloromethane
T=25°C; 0.75 h;
参考文献
Dhokte, U. P.; Rao, A. S.
Synthetic Communications, 1988 , vol. 18, # 8 p. 811 - 822
参考文献
Pu, Xiaotao; Ma, Dawei
Journal of Organic Chemistry, 2006 , vol. 71, # 17 p. 6562 - 6572
反应条件
diisobutylaluminium hydride in hexane; toluene
2 h;
参考文献
Ayyangar, N R; Argade, A B; Mehendale, A R; Deshpande, V H
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1992 , vol. 31, # 1 p. 3 - 8
反应条件
1: 89 percent / p-toluenesulfonic acid / Heating
2: 90 percent / LiAlH4 / diethyl ether / 25 °C
3: 65 percent / pyridinium chlorochromate / CH2Cl2 / 25 °C
View Scheme
参考文献
Ameer, Farouk; Giles, Robin G.F.; Green, Ivan R.; Nagabhushana, Kyatanahalli S.
Synthetic Communications, 2002 , vol. 32, # 3 p. 369 - 380
反应条件
bis[(S,S,S)-DiazaPhos-SPE]; [rhodium(I)(carbonyl)2(acetylacetonate)]; hydrogen in tetrahydrofuran; toluene
T=40°C; P=8000.32 Torr; 4 h; optical yield given as percent eeenantioselective reaction;
参考文献
McDonald, Richard I.; Wong, Gene W.; Neupane, Ram P.; Stahl, Shannon S.; Landis, Clark R.
Journal of the American Chemical Society, 2010 , vol. 132, # 40 p. 14027 - 14029
反应条件
1.1: 94 percent / TsOH / benzene
2.1: O3 / CH2Cl2 / -78 °C
2.2: PPh3
View Scheme
参考文献
Lee, Hee-Yoon; Kim, Won-Yeob; Lee, Sejin
Tetrahedron Letters, 2007 , vol. 48, # 8 p. 1407 - 1410
反应条件
1: TsOH / benzene / Heating
2: 5.80 g / LiAlH4 / tetrahydrofuran / 3 h / 20 °C
3: 2.01 g / DMSO; (COCl)2; Et3N / CH2Cl2 / 1.5 h / -78 °C
View Scheme
参考文献
Wu, Yikang; Li, Yan; Wu, Yu-Lin
Helvetica Chimica Acta, 2001 , vol. 84, # 1 p. 163 - 171
反应条件
1: 60 percent / H2SO4
2: TsOH / benzene / Heating
3: 5.80 g / LiAlH4 / tetrahydrofuran / 3 h / 20 °C
4: 2.01 g / DMSO; (COCl)2; Et3N / CH2Cl2 / 1.5 h / -78 °C
View Scheme
参考文献
Wu, Yikang; Li, Yan; Wu, Yu-Lin
Helvetica Chimica Acta, 2001 , vol. 84, # 1 p. 163 - 171
