3-(2-甲基-1,3-二氧戊环-2-基)丙醛合成路线 （共 21 条）
反应条件
ozone; triphenylphosphine
1) CH2Cl2, -70 deg C, 2) -70 deg C -> rt; Yield given. Multistep reaction;
参考文献
Zhou; Wei
Synthesis, 1990 , # 9 p. 822 - 824
反应条件
1: 95 percent
2: 1) O3, 2) PPh3 / 1) CH2Cl2, -70 deg C, 2) -70 deg C -> rt
View Scheme
参考文献
Zhou; Wei
Synthesis, 1990 , # 9 p. 822 - 824
反应条件
diisobutylaluminium hydride; toluene-4-sulfonic acid
1.) C6H6, reflux, 8 h; 2.) -78 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Argade; Mehendale; Ayyanger
Tetrahedron Letters, 1986 , vol. 27, # 30 p. 3529 - 3532
反应条件
1.) acetalisation, 2.) ozonolysis; the product slowly disappeared with time; Multistep reaction;
参考文献
Bowers, Kevin G.; Mann, John; Walsh, E. Brian; Howarth, Oliver W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1657 - 1666
反应条件
n-butyllithium
1) THF, 0.5 h, room temperature, 2) 3 h, room temperature; Yield given. Multistep reaction;
参考文献
Joshi, N. N.; Mamdapur, V. R.; Chadha, M. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 6 p. 577 - 579
反应条件
1: 1.) sodium hydride / 1.) ether, 25 deg C, 45 min, 2.) 3 h
2: 98 percent / hydrogen / 5percent Pd-C / methanol / 12 h / 25 °C
3: 93 percent / lithium aluminum hydride / diethyl ether / 2 h / 0 °C
4: 86 percent / hydrochloric acid / diethyl ether / 3 h / 25 °C
5: 97 percent / pyridine
6: 1.) sodium iodide, 2.) DBU / 1.) DMF, 50 deg C, 3.5 h, 2.) 80 deg C, 3.5 h
7: 1.) sodium hydride, 3.) aluminum chloride, lithium aluminum hydride / 1.) ether, 25 deg C, 1 h, 2.) 10 h, 3.) 0 deg C, 1 h
View Scheme
参考文献
Dhokte, U. P.; Rao, A. S.
Synthetic Communications, 1988 , vol. 18, # 8 p. 811 - 822
反应条件
1: 1.) sodium hydride / 1.) ether, 25 deg C, 45 min, 2.) 3 h
2: 98 percent / hydrogen / 5percent Pd-C / methanol / 12 h / 25 °C
3: 93 percent / lithium aluminum hydride / diethyl ether / 2 h / 0 °C
4: 86 percent / hydrochloric acid / diethyl ether / 3 h / 25 °C
5: 97 percent / pyridine
6: 1.) sodium iodide, 2.) DBU / 1.) DMF, 50 deg C, 3.5 h, 2.) 80 deg C, 3.5 h
View Scheme
参考文献
Dhokte, U. P.; Rao, A. S.
Synthetic Communications, 1988 , vol. 18, # 8 p. 811 - 822
反应条件
1: 1.) sodium hydride / 1.) ether, 25 deg C, 45 min, 2.) 3 h
2: 98 percent / hydrogen / 5percent Pd-C / methanol / 12 h / 25 °C
3: 86 percent / hydrochloric acid / diethyl ether / 1 h / 25 °C
View Scheme
参考文献
Dhokte, U. P.; Rao, A. S.
Synthetic Communications, 1988 , vol. 18, # 8 p. 811 - 822
反应条件
1: 1.) sodium hydride / 1.) ether, 25 deg C, 45 min, 2.) 3 h
2: 98 percent / hydrogen / 5percent Pd-C / methanol / 12 h / 25 °C
3: 93 percent / lithium aluminum hydride / diethyl ether / 2 h / 0 °C
4: 86 percent / hydrochloric acid / diethyl ether / 3 h / 25 °C
5: 97 percent / pyridine
6: 1.) sodium iodide, 2.) DBU / 1.) DMF, 50 deg C, 3.5 h, 2.) 80 deg C, 3.5 h
7: 1.) sodium hydride, 3.) aluminum chloride, lithium aluminum hydride / 1.) ether, 25 deg C, 1 h, 2.) 10 h, 3.) 0 deg C, 1 h
View Scheme
参考文献
Dhokte, U. P.; Rao, A. S.
Synthetic Communications, 1988 , vol. 18, # 8 p. 811 - 822
反应条件
1: 1.) sodium hydride / 1.) ether, 25 deg C, 45 min, 2.) 3 h
2: 98 percent / hydrogen / 5percent Pd-C / methanol / 12 h / 25 °C
3: 93 percent / lithium aluminum hydride / diethyl ether / 2 h / 0 °C
4: 95 percent / pyridine
5: 1.) sodium iodide, 2.) DBU / 1.) DMF, 50 deg C, 3.5 h, 2.) 80 deg C, 3.5 h
6: 95 percent / m-chloroperbenzoic acid
View Scheme
参考文献
Dhokte, U. P.; Rao, A. S.
Synthetic Communications, 1988 , vol. 18, # 8 p. 811 - 822
