1-甲烷磺酰基哌啶-4-甲醇合成路线 （共 5 条）
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-70°C; 0.833333 h; Molecular sieve; 2: With triethylamine in dichloromethane T=-70 - 20°C; 3: With hydrogenchloride in dichloromethane; water T=0°C; Product distribution / selectivity;
参考文献
AstraZeneca AB
Patent: US2008/139613 A1, 2008 ;
Location in patent: Page/Page column 8 ;
US 20080139613 A1
反应条件
triethylamine in dichloromethane; dimethyl sulfoxide
参考文献
Syntex (U.S.A.) LLC
Patent: US6319920 B1, 2001 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C;
2: With water in tetrahydrofuran
T=0 - 10°C;
3: With hydrogenchloride in tetrahydrofuran; water
T=0 - 20°C; pH=< 2; 0.25 h;
参考文献
AstraZeneca AB
Patent: US2008/139613 A1, 2008 ;
Location in patent: Page/Page column 7 ;
US 20080139613 A1
反应条件
1: triethylamine / CH2Cl2 / 0 °C
2: lithium aluminum hydride / tetrahydrofuran / 0 °C
View Scheme
参考文献
Chang, Meng-Yang; Kung, Yung-Hua; Ma, Chih-Chong
Tetrahedron Letters, 2007 , vol. 48, # 2 p. 199 - 202
反应条件
1: pyridinium chlorochromate; Celite / CH2Cl2 / 20 °C
2: tetrahydrofuran / -78 °C
3: pyridinium chlorochromate; Celite / CH2Cl2 / 20 °C
View Scheme
参考文献
Chang, Meng-Yang; Kung, Yung-Hua; Ma, Chih-Chong
Tetrahedron Letters, 2007 , vol. 48, # 2 p. 199 - 202
