1-(甲基磺酰基)-4-哌啶羧醛合成路线 （共 6 条）
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-70°C; 0.833333 h; Molecular sieve; 2: With triethylamine in dichloromethane T=-70 - 20°C; 3: With hydrogenchloride in dichloromethane; water T=0°C; Product distribution / selectivity;
参考文献
AstraZeneca AB
Patent: US2008/139613 A1, 2008 ;
Location in patent: Page/Page column 8 ;
US 20080139613 A1
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; dichloromethane T=-77 - -75°C; 3 h; 2: With water; ammonium chloride in tetrahydrofuran; dichloromethane T=-67°C; 0.5 h; Product distribution / selectivity;
参考文献
AstraZeneca AB
Patent: US2008/139613 A1, 2008 ;
Location in patent: Page/Page column 8 ;
US 20080139613 A1
反应条件
triethylamine in dichloromethane; dimethyl sulfoxide
参考文献
Syntex (U.S.A.) LLC
Patent: US6319920 B1, 2001 ;
反应条件
1: triethylamine / CH2Cl2 / 0 °C 2: lithium aluminum hydride / tetrahydrofuran / 0 °C 3: pyridinium chlorochromate; Celite / CH2Cl2 / 20 °C View Scheme
参考文献
Brock, Sally; Hose, David R.J.; Moseley, Jonathan D.; Parker, Alexandra J.; Patel, Ian; Williams, Andrew J.
Organic Process Research and Development, 2008 , vol. 12, # 3 p. 496 - 502
反应条件
piperidine in pyridine; toluene
T=87 - 106°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/57643 A1, 2007 ;
Location in patent: Page/Page column 10-11 ;
WO 2007/057643 A1
反应条件
1: tetrahydrofuran / -78 °C
2: pyridinium chlorochromate; Celite / CH2Cl2 / 20 °C
View Scheme
参考文献
Chang, Meng-Yang; Kung, Yung-Hua; Ma, Chih-Chong
Tetrahedron Letters, 2007 , vol. 48, # 2 p. 199 - 202
