1,1'-(2,3-二甲基-1,4-丁烷二基)二(3,4-二甲氧基苯)合成路线 （共 31 条）
反应条件
1: 73 percent / hydrogen / 10 percent palladium on charcoal / acetic acid / 4 h / Ambient temperature 2: 82 percent / CaCl2, NaBH4 / ethanol / 0.25 h / Ambient temperature 3: 98 percent / pyridine / 0.33 h / 0 °C 4: 90 percent / LiBEt3 / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 50, # 4 p. 1153 - 1164
反应条件
1,1'-bis(diphenylphosphanyl)ferrocenenickel(II) chloride in tetrahydrofuran 96 h;
参考文献
Kramer, Beate; Averhoff, Anne; Waldvogel, Siegfried R
Angewandte Chemie (International ed. in English), 2002 , vol. 41, # 16 p. 2981 - 2982
反应条件
tetrahydrofuran; lithium aluminium tetrahydride
参考文献
Journal of the American Chemical Society, , vol. 79, p. 3823,3825
反应条件
1: methanol. H2SO4 2: sodium ethylate; ethanol / anschliessend Erwaermen unter Zusatz von H2O 3: Raney nickel; aluminium; aqueous NaOH / 90 °C / Hydrogenation 4: methanol; acetone; diethyl ether 5: LiAlH4; THF 7: LiAlH4; THF View Scheme
参考文献
Journal of the American Chemical Society, , vol. 79, p. 3823,3825
反应条件
1: sodium ethylate; ethanol / anschliessend Erwaermen unter Zusatz von H2O 2: Raney nickel; aluminium; aqueous NaOH / 90 °C / Hydrogenation 3: methanol; acetone; diethyl ether 4: LiAlH4; THF 6: LiAlH4; THF View Scheme
参考文献
Journal of the American Chemical Society, , vol. 79, p. 3823,3825
反应条件
1: Raney nickel; aluminium; aqueous NaOH / 90 °C / Hydrogenation 2: methanol; acetone; diethyl ether 3: LiAlH4; THF 5: LiAlH4; THF View Scheme
参考文献
Journal of the American Chemical Society, , vol. 79, p. 3823,3825
反应条件
1: methanol; acetone; diethyl ether 2: LiAlH4; THF 4: LiAlH4; THF View Scheme
参考文献
Journal of the American Chemical Society, , vol. 79, p. 3823,3825
反应条件
1: LiAlH4; THF 3: LiAlH4; THF View Scheme
参考文献
Journal of the American Chemical Society, , vol. 79, p. 3823,3825
反应条件
1: 82 percent / CaCl2, NaBH4 / ethanol / 0.25 h / Ambient temperature 2: 98 percent / pyridine / 0.33 h / 0 °C 3: 90 percent / LiBEt3 / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 50, # 4 p. 1153 - 1164
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 - 7 °C / |Inert atmosphere 1.2: 0.28 h / 18 °C 1.3: 0.67 h / -70 - -55 °C 2.1: hydrogenchloride / methanol / 6.5 h / 44 - 54 °C / |Inert atmosphere; |Large scale 3.1: palladium 10 on activated carbon; hydrogen / 1-Propyl acetate / 8 h / 100 °C / 51716.2 Torr View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 62, p. 605 - 613
