1,1'-(2,3-二甲基-1,4-丁烷二基)二(3,4-二甲氧基苯)合成路线 （共 31 条）
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 0.42 h / -10 - 2 °C / |Inert atmosphere 1.2: 0.42 h / -4 - 1 °C / |Inert atmosphere 2.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 - 7 °C / |Inert atmosphere 2.2: 0.28 h / 18 °C 2.3: 0.67 h / -70 - -55 °C 3.1: hydrogenchloride / methanol / 6.5 h / 44 - 54 °C / |Inert atmosphere; |Large scale 4.1: palladium 10 on activated carbon; hydrogen / 1-Propyl acetate / 8 h / 100 °C / 51716.2 Torr View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 62, p. 605 - 613
反应条件
potassium carbonate in acetone
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 27, # 7 p. 1583 - 1588
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 - 7 °C / |Inert atmosphere 1.2: 0.28 h / 18 °C 1.3: 0.67 h / -70 - -55 °C 2.1: hydrogenchloride / methanol / 6.5 h / 44 - 54 °C / |Inert atmosphere; |Large scale 3.1: palladium 10 on activated carbon; hydrogen / 1-Propyl acetate / 8 h / 100 °C / 51716.2 Torr View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 62, p. 605 - 613
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 - 7 °C / |Inert atmosphere 1.2: 0.28 h / 18 °C 1.3: 0.67 h / -70 - -55 °C 2.1: hydrogenchloride / methanol / 6.5 h / 44 - 54 °C / |Inert atmosphere; |Large scale 3.1: palladium 10 on activated carbon; hydrogen / 1-Propyl acetate / 3 h / 100 °C / 51716.2 Torr View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 62, p. 605 - 613
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 0.42 h / -10 - 2 °C / |Inert atmosphere 1.2: 0.42 h / -4 - 1 °C / |Inert atmosphere 2.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 - 7 °C / |Inert atmosphere 2.2: 0.28 h / 18 °C 2.3: 0.67 h / -70 - -55 °C 3.1: hydrogenchloride / methanol / 6.5 h / 44 - 54 °C / |Inert atmosphere; |Large scale 4.1: palladium 10 on activated carbon; hydrogen / 1-Propyl acetate / 3 h / 100 °C / 51716.2 Torr View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 62, p. 605 - 613
反应条件
in methanol; hexane T=20°C; 15 h;
参考文献
Yokosuka, Akihito; Matsuo, Yukiko; Jitsuno, Maki; Adachi, Kohei; Mimaki, Yoshihiro
Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 12 p. 1467 - 1470
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 - 7 °C / |Inert atmosphere 1.2: 0.28 h / 18 °C 1.3: 0.67 h / -70 - -55 °C 2.1: hydrogenchloride / methanol / 6.5 h / 44 - 54 °C / |Inert atmosphere; |Large scale 3.1: palladium 10 on activated carbon; hydrogen / 1-Propyl acetate / 3 h / 100 °C / 51716.2 Torr View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 62, p. 605 - 613
反应条件
1: hydrogenchloride / methanol / 6.5 h / 44 - 54 °C / |Inert atmosphere; |Large scale 2: palladium 10 on activated carbon; hydrogen / 1-Propyl acetate / 3 h / 100 °C / 51716.2 Torr View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 62, p. 605 - 613
反应条件
boron trichloride; potassium carbonate 1.) CH2Cl2, r.t., 6 h; 2.) acetone, 40 deg C, 5 h; Yield given. Multistep reaction;
参考文献
Phytochemistry (Elsevier), , vol. 26, # 5 p. 1542 - 1543
反应条件
in methanol; diethyl ether 72 h;
参考文献
Sakurai; Nikaido; Ohmoto; Ikeya; Mitsuhashi
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 5 p. 1191 - 1195
