3',4'-二甲氧基-7-羟基异黄酮合成路线 （共 11 条）
反应条件
1: With boron tribromide in dichloromethane T=0 - 20°C; 6 h; 2: With water in dichloromethane T=0°C;
参考文献
Matin, Azadeh; Gavande, Navnath; Kim, Moon S.; Yang, Nancy X.; Salam, Noeris K.; Hanrahan, Jane R.; Roubin, Rebecca H.; Hibbs, David E.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6835 - 6850
反应条件
toluene-4-sulfonic acid in tetrahydrofuran; methanol
T=20 - 60°C; 1 h;
参考文献
THE UNIVERSITY OF SYDNEY
Patent: WO2009/26657 A1, 2009 ;
Location in patent: Page/Page column 36; 67 ;
WO 2009/026657 A1
反应条件
1: With boron trifluoride diethyl etherate
T=100°C; 1 h; Reflux;
2: With N,N-dimethyl-formamide dimethyl acetal in toluene
2 h;
参考文献
CHINA PHARMACEUTICAL UNIVERSITY; Xiang, Hua; Zhao, Wei; Xiao, Hong; Yao, Yao; Ma, Renling; Qian, Lei; Li, Xiaobo; You, Qidong; Liao, Qingjiang
Patent: US2013/79393 A1, 2013 ;
Location in patent: Paragraph 0144; 0145 ;
反应条件
boron trifluoride diethyl etherate; methanesulfonyl chloride
T=50 - 110°C; 2 h; Inert atmosphere;
参考文献
Deodhar, Mandar; Wood, Kasey; Black, David Stclair; Kumar, Naresh
Australian Journal of Chemistry, 2012 , vol. 65, # 10 p. 1377 - 1383,7
反应条件
in morpholine; N-methyl-acetamide; chloroform
参考文献
Chinoin Gyogyszer- es Vegyeszeti Termekek Gyara Rt.
Patent: US5247102 A1, 1993 ;
反应条件
1: 1-(2,4-dihydroxyphenyl)-2-(3,4-dimethoxyphenyl)ethan-1-one With boron trifluoride diethyl etherate in N,N-dimethyl-formamide
T=0°C;
2: methanesulfonyl chloride T=100°C; 2 h;
参考文献
Yadav, Dinesh K.; Gautam, Abnish K.; Kureel, Jyoti; Srivastava, Kamini; Sahai, Mahendra; Singh, Divya; Chattopadhyay, Naibedya; Maurya, Rakesh
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 2 p. 677 - 681
反应条件
1.1: boron trifluoride diethyl etherate / 80 - 100 °C
2.1: boron trifluoride diethyl etherate / N,N-dimethyl-formamide / 0 °C
2.2: 2 h / 100 °C
View Scheme
参考文献
Yadav, Dinesh K.; Gautam, Abnish K.; Kureel, Jyoti; Srivastava, Kamini; Sahai, Mahendra; Singh, Divya; Chattopadhyay, Naibedya; Maurya, Rakesh
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 2 p. 677 - 681
反应条件
1.1: boron trifluoride diethyl etherate / 80 - 100 °C
2.1: boron trifluoride diethyl etherate / N,N-dimethyl-formamide / 0 °C
2.2: 2 h / 100 °C
View Scheme
参考文献
Yadav, Dinesh K.; Gautam, Abnish K.; Kureel, Jyoti; Srivastava, Kamini; Sahai, Mahendra; Singh, Divya; Chattopadhyay, Naibedya; Maurya, Rakesh
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 2 p. 677 - 681
反应条件
hydrogenchloride; ethanol
参考文献
Dhar et al.
Journal of Scientific and Industrial Research, 1955 , vol. 14 B, p. 73
反应条件
hydrogenchloride; diethyl ether
Erhitzen des Reaktionsprodukts mit Wasser;
参考文献
Farkas et al.
Chemische Berichte, 1958 , vol. 91, p. 2858,2860
