5-甲基嘧啶-2,4,6(1H,3H,5H)-三酮合成路线 （共 34 条）
参考文献
Hughes; Macbeth
Journal of the Chemical Society, 1938 , p. 1622
反应条件
1.1: N-benzyl-N,N,N-triethylammonium chloride; trichlorophosphate / 7 h / 50 °C / Inert atmosphere 2.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane / 2 h / 20 °C / Inert atmosphere 2.2: 2 h / 0 °C / Inert atmosphere 3.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Puig-De-La-Bellacasa, Raimon; Gimenez, Laura; Pettersson, Sofia; Pascual, Rosalia; Gonzalo, Encarna; Este, Jose A.; Clotet, Bonaventura; Borrell, Jose I.; Teixido, Jordi
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 159 - 174
反应条件
sodium hydroxide T=100°C; unter Druck;
参考文献
Gebr. von Niessen
Patent: DE144432 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 7, p. 658
参考文献
Fahr, Egon; Fecher, Peter; Roth, Georg; Wuestenfeld, Peter
Angewandte Chemie, 1980 , vol. 92, # 10 p. 858 - 859
反应条件
phosphorus; hydrogen iodide
参考文献
Johnson; Chernoff
Journal of the American Chemical Society, 1914 , vol. 36, p. 1746
参考文献
Fahr, Egon; Fecher, Peter; Roth, Georg; Wuestenfeld, Peter
Angewandte Chemie, 1980 , vol. 92, # 10 p. 858 - 859
反应条件
1: 65 percent / POCl3; H3PO4 / 0.75 h / 100 °C 2: 71 percent / NaI; HI / 24 h / 20 °C 3: 40 percent / LiCl; MeMgCl / tetrahydrofuran / 0.33 h / -30 °C View Scheme
参考文献
Kopp, Felix; Knoechel, Paul
Organic Letters, 2007 , vol. 9, # 9 p. 1639 - 1641
反应条件
1.1: N-benzyl-N,N,N-triethylammonium chloride; trichlorophosphate / 7 h / 50 °C / Inert atmosphere 2.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane / 2 h / 20 °C / Inert atmosphere 2.2: 2 h / 0 °C / Inert atmosphere 3.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Puig-De-La-Bellacasa, Raimon; Gimenez, Laura; Pettersson, Sofia; Pascual, Rosalia; Gonzalo, Encarna; Este, Jose A.; Clotet, Bonaventura; Borrell, Jose I.; Teixido, Jordi
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 159 - 174
反应条件
phosphoric acid; trichlorophosphate T=100°C; 0.75 h;
参考文献
Organic Letters, , vol. 9, # 9 p. 1639 - 1641
反应条件
N-benzyl-N,N,N-triethylammonium chloride; trichlorophosphate T=50°C; 7 h; Inert atmosphere;
参考文献
Puig-De-La-Bellacasa, Raimon; Gimenez, Laura; Pettersson, Sofia; Pascual, Rosalia; Gonzalo, Encarna; Este, Jose A.; Clotet, Bonaventura; Borrell, Jose I.; Teixido, Jordi
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 159 - 174
