Nε-Boc-L-赖氨酸合成路线 （共 24 条）
反应条件
in tetrahydrofuran; water T=60°C; pH=12; 18 h; Product distribution / selectivity;
参考文献
F.I.S. FABBRICA ITALIANA SINTETICI S.P.A
Patent: WO2008/14811 A1, 2008 ;
Location in patent: Page/Page column 16 ;
反应条件
piperidine in N,N-dimethyl-formamide 0.5 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 4 p. 987 - 993
反应条件
sodium hydroxide; sodium hydrogencarbonate
参考文献
Chemistry of Natural Compounds, , vol. 15, p. 471 - 476
Khimiya Prirodnykh Soedinenii, , vol. 15, p. 543 - 548
参考文献
Justus Liebigs Annalen der Chemie, , vol. 716, p. 216 - 218
反应条件
platinum(IV) oxide; Pt/titania in water 41 h; IrradiationpH 4.6;
参考文献
Ohtani, Bunsho; Tsuru, Shigeto; Nishimoto, Sei-ichi; Kagiya, Tsutomu
Journal of Organic Chemistry, 1990 , vol. 55, # 21 p. 5551 - 5553
反应条件
1: 94 percent / aq. alkali 2: oxalyl chloride / CH2Cl2; dimethylformamide / 1 h / 0 °C 3: CH2Cl2 / 1 h / Ambient temperature 4: 93 percent / TFA / 10 - 15 °C 5: 1.) 4-formyl-1-methylpyridinium benzenesulfonate, 2.) DBU, 3.) aq. oxalic acid / 1) CH2Cl2, DMF, room temperature; 2) 5 min; 3) cooling, 0.5 - 1 h 6: 1.) Jones reagent, 2.) aq. HCl / 1) room temperature, acetone; 2) heating 7: 85 percent / 0.5 h / 170 °C View Scheme
参考文献
Buckley, Thomas F.; Rapoport, Henry
Journal of the American Chemical Society, 1982 , vol. 104, # 16 p. 4446 - 4450
反应条件
sodium hydrogencarbonate; dicyclohexyl-carbodiimide 1.) acetone, water, r.t., 2.) ethyl acetate, 0 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Schoen, Istvan; Kisfaludy, Lajos
Synthesis, 1986 , # 4 p. 303 - 305
反应条件
sodium carbonate in water; acetone Acylation; 1 h;
参考文献
Wiejak, Stanislaw; Masiukiewicz, Elzbieta; Rzeszotarska, Barbara
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 10 p. 1489 - 1490
反应条件
1: 94 percent / aq. alkali 2: oxalyl chloride / CH2Cl2; dimethylformamide / 1 h / 0 °C 3: CH2Cl2 / 1 h / Ambient temperature 4: 93 percent / TFA / 10 - 15 °C 5: 1.) 4-formyl-1-methylpyridinium benzenesulfonate, 2.) DBU, 3.) aq. oxalic acid / 1) CH2Cl2, DMF, room temperature; 2) 5 min; 3) cooling, 0.5 - 1 h 6: 1.) Jones reagent, 2.) aq. HCl / 1) room temperature, acetone; 2) heating View Scheme
参考文献
Buckley, Thomas F.; Rapoport, Henry
Journal of the American Chemical Society, 1982 , vol. 104, # 16 p. 4446 - 4450
反应条件
triethylamine in water; N,N-dimethyl-formamide pH 9;
参考文献
Maeda; Okada; Sogabe; Kawasaki
Chemical and pharmaceutical bulletin, 1985 , vol. 33, # 5 p. 2137 - 2141
