4-(((吡啶-3-基甲氧基)羰基氨基)甲基)苯甲酸合成路线 （共 7 条）
反应条件
1: pyridine-3-methanol; 1,1'-carbonyldiimidazole in tetrahydrofuran T=0 - 10°C; 1.16667 h; 2: 4-aminomethyl-benzoic acid With sodium hydroxide in tetrahydrofuran; water T=20°C; 4 h; 3: With hydrogenchloride in tetrahydrofuran; water pH=4.5;
参考文献
JIANGSU GOWORTH INVESTMENT CO. LTD; SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY
Patent: US2011/152323 A1, 2011 ;
Location in patent: Page/Page column 19-20 ;
US 20110152323 A1
反应条件
hydrogenchloride; sodium hydroxide; sodium chloride; 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide
参考文献
Mitsui Chemicals, Inc.
Patent: US6320078 B1, 2001 ;
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine in tetrahydrofuran 5 h; Ambient temperature; Yield given;
参考文献
Gediya, Lalji K.; Belosay, Aashvini; Khandelwal, Aakanksha; Purushottamachar, Puranik; Njar, Vincent C.O.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 6 p. 3352 - 3360
反应条件
1: tetrahydrofuran / 1 h / Ambient temperature 2: DBU, Et3N / tetrahydrofuran / 5 h / Ambient temperature View Scheme
参考文献
Suzuki, Tsuneji; Ando, Tomoyuki; Tsuchiya, Katsutoshi; Fukazawa, Nobuyuki; Saito, Akiko; Mariko, Yukiyasu; Yamashita, Takashi; Nakanishi, Osamu
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 3001 - 3003
反应条件
1: 4-lt;N-(pyridin-3-ylmethylcarbonyl)aminomethylgt;benzoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=60°C; 3 h; 2: 1,2-diamino-benzene With trifluoroacetic acid in tetrahydrofuran T=20°C; 16 h;
参考文献
WO2009/76206 A1, ;
Page/Page column 16-17 ;
WO 2009/076206 A1
反应条件
methanesulfonic acid in water; 1,1'-carbonyldiimidazole
反应条件
1: (COCl)2, DMF / toluene / 4 h 2: tetrahydrofuran / 1 h / Ambient temperature 3: TFA / tetrahydrofuran / 15 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 15 p. 3001 - 3003
