2-噁唑-7-氮杂螺[3.5]壬烷合成路线 （共 6 条）
反应条件
hydrogen; palladium(II) oxide hydrate in methanol T=20°C;
参考文献
AMGEN INC.; ALLEN, Jennifer R.; CHEN, Jian J.; FROHN, Michael J.; HU, Essa; LIU, Qingyian; PICKRELL, Alexander J.; RUMFELT, Shannon; RZASA, Robert M.; ZHONG, Wenge
Patent: WO2011/143365 A1, 2011 ;
Location in patent: Page/Page column 191 ;
WO 2011/143365 A1
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 3 h;
参考文献
Castro Pineiro, Jose Luis; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John
Patent: US2003/236250 A1, 2003 ;
Location in patent: Page 28 ;
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C;
参考文献
Tetrahedron Letters, , vol. 52, # 26 p. 3266 - 3270
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C 1.2: 4 h / 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C 3.1: triethylamine / dichloromethane / 0 - 20 °C 4.1: triethylamine / acetonitrile / 12 h / Reflux 5.1: hydrogen / palladium(II) oxide hydrate / methanol / 20 °C View Scheme
参考文献
WO2011/143365 A1, ;
WO 2011/143365 A1
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C 2: triethylamine / dichloromethane / 0 - 20 °C 3: triethylamine / acetonitrile / 12 h / Reflux 4: hydrogen / palladium(II) oxide hydrate / methanol / 20 °C View Scheme
参考文献
WO2011/143365 A1, ;
WO 2011/143365 A1
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C 2: triethylamine / acetonitrile / 12 h / Reflux 3: hydrogen / palladium(II) oxide hydrate / methanol / 20 °C View Scheme
参考文献
WO2011/143365 A1, ;
WO 2011/143365 A1
