(alphaS)-1,3-二氢-alpha-(2-甲基丙基)-1,3-二氧代-2H-异吲哚-2-乙酸合成路线 （共 15 条）
反应条件
sodium carbonate in water T=20°C; 2 h;
参考文献
WO2010/20055 A1, ;
Page/Page column 68 ;
反应条件
T=140°C; 0.166667 h;
参考文献
Chemische Berichte, , vol. 125, # 11 p. 2467 - 2476
反应条件
1: 2-(1,3-dioxo-2-azaindane-2-yl)-4-methylpentanoic acid With benzoic acid anhydride; dicyclohexyl-carbodiimide in toluene T=20°C; 0.25 h; 2: (α-Np)2CHOH With (S)-HBTM; N-ethyl-N,N-diisopropylamine in toluene T=20°C; 24 h; optical yield given as percent ee;
参考文献
Chemistry - A European Journal, , vol. 17, # 40 p. 11296 - 11304
反应条件
hydrogenchloride; potassium chloride in acetonitrile T=50°C; pH=1.00; KineticsProduct distribution; Further Variations:pH-values;
参考文献
Journal of the Chemical Society, Perkin Transactions 2, , # 9 p. 1863 - 1868
参考文献
Reese
Justus Liebigs Annalen der Chemie, 1887 , vol. 242, p. 1
参考文献
Reese
Justus Liebigs Annalen der Chemie, 1887 , vol. 242, p. 1
反应条件
bei der trocknen Destillation;
参考文献
Reese
Justus Liebigs Annalen der Chemie, 1887 , vol. 242, p. 1
反应条件
1: SOCl2 / benzene / 6 h / Heating 2: H2 / 5percent Pd/BaSO4 / xylene / 6 h / 110 °C 3: 100 percent / ZnI2 / CH2Cl2 / 12 h / Ambient temperature 4: 10percent aq. HCl / 1.5 h 5: 6 N aq. HCl / dioxane / 48 h / Heating 6: 100 percent / NEt3 / H2O; dioxane / Ambient temperature View Scheme
参考文献
Johnson, Rodney L.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 5 p. 605 - 610
反应条件
1: SOCl2 / benzene / 6 h / Heating 2: H2 / 5percent Pd/BaSO4 / xylene / 6 h / 110 °C 3: NaBH4 / ethanol / 0.5 h / 4 °C 4: conc. HCl / dioxane / 24 h / Heating View Scheme
参考文献
Johnson, Rodney L.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 5 p. 605 - 610
反应条件
1: thionyl chloride / und Behandeln des Reaktionsprodukts mit Diazomethan in Aether 2: silver oxide 3: aqueous HI; acetic acid View Scheme
参考文献
Arhiv za Kemiju, , vol. 23, p. 1
