4-乙酰氨基-5-氯-2-羟基苯甲酸甲酯合成路线 （共 8 条）
反应条件
N-chloro-succinimide in 1,2-dichloro-ethane 3 h; Reflux;
参考文献
WO2013/42135 A1, ;
Page/Page column 11 ;
反应条件
1: With boron trichloride in dichloromethane T=0 - 15°C; 4 h; 2: With water in dichloromethane
参考文献
WO2007/96352 A1, ;
Page/Page column 12; 23-24 ;
WO 2007/096352 A1
反应条件
potassium hydroxide in tetrahydrofuran; ethanol; water
反应条件
PPh3 gold(I) chloro complex; silver trifluoromethanesulfonate in 2-methyl tetrahydrofuran T=70°C; 6 h; Inert atmosphere;
参考文献
Tetrahedron Letters, , vol. 49, # 44 p. 6279 - 6281
反应条件
1: 58 percent / pyridine / CHCl3 / 2 h 2: 80 percent / SO2Cl2 / CHCl3 / 3 h / 25 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 6, # 22 p. 2657 - 2662
反应条件
1: 53 percent / H2SO4 / 36 h / Heating 2: 58 percent / pyridine / CHCl3 / 2 h 3: 80 percent / SO2Cl2 / CHCl3 / 3 h / 25 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 6, # 22 p. 2657 - 2662
反应条件
1: 77 percent / NaI, chloramine-T / dimethylformamide / 1 h / 10 °C 2: 62 percent / K2CO3 / acetone / 2 h / Heating 3: 70 percent / NaOH / ethanol / 0.5 h / 80 °C 4: 73 percent / NaOH / ethanol / 16 h / Heating View Scheme
参考文献
De Paulis, Tomas; Trivedi, Bakula L.; Zhang, Zhang-Jin; Schmidt, Dennis E.; Ebert, Michael H.; Hewlett, William A.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 22 p. 2657 - 2662
反应条件
1: methyl 4-acetylamino-5-chloro-2-hydroxybenzoate With sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide
T=12 - 20°C; 1.66 h;
2: propargyl bromide in tetrahydrofuran; N,N-dimethyl-formamide; toluene
T=20°C; 40 h; Heating / reflux;
3: With sodium hydroxide; water in dichloromethane
参考文献
SUVEN LIFE SCIENCES LIMITED; Nirogi, Ramakrishna; Mohammed, Abdul Rasheed; Yarlagadda, Suresh; Ravella, Srinivasa Rao; Shinde, Anil Karbhari; Kamphampati, Ramasastri; Roayapalley, Praveen Kumar; Jayarajan, Pradeep; Bhyrapuneni, Gopinadh; Patnala, Sriramachandra Murthy; Ravula, Jyothsna; Jasti, Venkateswarlu
Patent: US2014/187581 A1, 2014 ;
Location in patent: Page/Page column ;
