7-氨基-3-(1-甲基-1H-四唑-5-硫代甲基)-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸合成路线 （共 12 条）
反应条件
pyridine; hydrogenchloride; sodium hydroxide; nitrogen in methanol; dichloromethane; water
反应条件
boron trifluoride in acetonitrile T=30°C; 1.5 h;
参考文献
Saikawa; Takano; Momonoi; et al.
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 12 p. 5534 - 5538
反应条件
1: iodotrimethylsilane / CH2Cl2 / 1 h 2: 1.) pyridine, 2.) MeOH / 1.) CH2Cl2, 2.) from 0 to 5 deg C, 15 min View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 5 p. 983 - 991
反应条件
1: iodotrimethylsilane (TMSI) / 1,1,2-trichloro-1,2,2-trifluoro-ethane / 2 h / 25 - 30 °C 2: 1.) pyridine, 2.) MeOH / 1.) freon TF, CH2Cl2, from 0 to 5 deg C, 30 min, 2.) from 0 to 5 deg, 10 min View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 5 p. 983 - 991
反应条件
pyridine; methanol 1.) freon TF, CH2Cl2, from 0 to 5 deg C, 30 min, 2.) from 0 to 5 deg, 10 min; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 53, # 5 p. 983 - 991
反应条件
pyridine; methanol 1.) CH2Cl2, 2.) from 0 to 5 deg C, 15 min; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 53, # 5 p. 983 - 991
反应条件
1.1: immobilized penicillin G acylase mutant 1 / water / 2 °C / pH 8.5 / |Enzymatic reaction 1.2: pH 4.3 2.1: 1H-imidazole / isopropanol acetate / 8 h / 20 °C 2.2: pH 2 3.1: sodium 2-ethyl hexanoate / isopropyl alcohol; acetone / 20 °C / pH 5.6 View Scheme
参考文献
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.; MOODY, Harold, Monro; MAAS, Peter, Johannes, Dominicus; SCHMITGES, Thomas
Patent: WO2013/57197 A1, 2013 ;
反应条件
3G3K penicillin G acylase immobilized on glyoxyl agarose T=4°C; pH=6.5; aq. phosphate bufferEnzymatic reaction;
参考文献
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.; MOODY, Harold, Monro; MAAS, Peter, Johannes, Dominicus; SCHMITGES, Thomas
Patent: WO2013/57197 A1, 2013 ;
Location in patent: Page/Page column 8 ;
反应条件
immobilized penicillin G acylase from Escherichia coli in phosphate buffer T=4°C; pH=6.5; Kinetics;
参考文献
Terreni, Marco; Tchamkam, Joseph Gapesie; Sarnataro, Umberto; Rocchietti, Silvia; Fernandez-Lafuente, Roberto; Guisan, Jose M.
Advanced Synthesis and Catalysis, 2005 , vol. 347, # 1 p. 121 - 128
反应条件
1: (i) MeOH, THF, (ii) /BRN= 982526/, (iii) /BRN= 3552389/, tBuOCl, ClCH2CH2Cl 2: PhNHNH2 / 1,2-dichloro-ethane 3: PhNEt2 / 1,2-dichloro-ethane View Scheme
参考文献
Yanagisawa; Fukushima; Ando; Nakao
Journal of Antibiotics, 1976 , vol. 29, # 9 p. 969 - 972
