2-氨基-6-甲基-4,5,6,7-四氢-噻吩酮[2,3-C]吡啶-3-羧酸乙酯合成路线 （共 2 条）
反应条件
morpholine; sulfur in ethanol T=60°C;
参考文献
Kling, Andreas; Lange, Udo E. W.; Mack, Helmut; Bakker, Margot H. M.; Drescher, Karla U.; Hornberger, Wilfried; Hutchins, Charles W.; Moeller, Achim; Mueller, Reinhold; Schmidt, Martin; Unger, Liliane; Wicke, Karsten; Schellhaas, Kurt; Steiner, Gerd
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 24 p. 5567 - 5573
反应条件
1: With water; sodium hydroxide in ethanol
T=80°C;
2: With hydrogenchloride in water
pH=Ca. 7; Cooling with ice;
参考文献
Aurelio, Luigi; Valant, Celine; Figler, Heidi; Flynn, Bernard L.; Linden, Joel; Sexton, Patrick M.; Christopoulos, Arthur; Scammells, Peter J.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 20 p. 7353 - 7361
