2-氨基-3,5-二溴吡嗪合成路线 （共 54 条）
反应条件
in ethanol
3 h; Heating;
参考文献
Abignente; Arena; de Caprariis; Nuzzetti; Marmo; Lampa; Rosatti; Ottavo
Farmaco, Edizione Scientifica, 1981 , vol. 36, # 1 p. 61 - 80
反应条件
1.) DMC, reflux, 3 h, 2.) EtOH, reflux, 1 h; Yield given. Multistep reaction;
参考文献
Sablayrolles; Cros; Milhavet; Rechenq; Chapat; Boucard; Serrano; McNeill
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 206 - 212
反应条件
caesium carbonate; Pd(PPh3)4 in 1,4-dioxane; ethanol; water; ethyl acetate
参考文献
Keegan, Kathleen S.; Kesicki, Edward A.; Gaudino, John Joseph; Cook, Adam Wade; Cowen, Scott Douglas; Burgess, Laurence Edward
Patent: US2003/69284 A1, 2003 ;
US 20030069284 A1
反应条件
N-ethyl-N,N-diisopropylamine in butan-1-ol
T=220°C; 1 h; Microwave irradiation;
参考文献
SIGNAL PHARMACEUTICALS, LLC
Patent: WO2008/51493 A2, 2008 ;
Location in patent: Page/Page column 77; 79-80 ;
反应条件
in butan-1-ol
48 h; Heating / reflux;
参考文献
SUGEN, INC.
Patent: WO2005/4607 A1, 2005 ;
Location in patent: Page/Page column 33 ;
WO 2005/004607 A1
反应条件
in methanol
3 h; Ambient temperature;
参考文献
Barlin
Australian Journal of Chemistry, 1983 , vol. 36, # 5 p. 983 - 992
反应条件
in carbonic acid dimethyl ester
T=20 - 110°C;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; KLAR, Ulrich; JAUTELAT, Rolf; KOSEMUND, Dirk; BOHLMANN, Rolf; BADER, Benjamin; LIENAU, Philip; SIEMEISTER, Gerhard
Patent: WO2012/80234 A1, 2012 ;
Location in patent: Page/Page column 45 ;
WO 2012/080234 A1
反应条件
1.) DMC, reflux, 3 h, 2.) EtOH, reflux, 1 h; Yield given. Multistep reaction;
参考文献
Sablayrolles; Cros; Milhavet; Rechenq; Chapat; Boucard; Serrano; McNeill
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 206 - 212
参考文献
Alcon, Inc.
Patent: US2006/142307 A1, 2006 ;
Location in patent: Page/Page column 5-6 ;
US 20060142307 A1
反应条件
hydrazine hydrate in water
1.25 h; Heating;
参考文献
Barlin; Ireland
Australian Journal of Chemistry, 1984 , vol. 37, # 5 p. 1057 - 1064
