2-氨基-3,5-二溴吡嗪合成路线 （共 54 条）
反应条件
bis(benzonitrile)palladium(II) dichloride; sodium carbonate; 1,4-di(diphenylphosphino)-butane in ethanol; water; toluene
Suzuki coupling; 7 h; Heating;
参考文献
Adamczyk, Maciej; Akireddy, Srinivasa Rao; Johnson, Donald D.; Mattingly, Phillip G.; Pan, You; Reddy, Rajarathnam E.
Tetrahedron, 2003 , vol. 59, # 41 p. 8129 - 8142
反应条件
1: phenol With sodium hydride in tetrahydrofuran
T=0°C; 0.5 h;
2: 3,5-dibromopyrazine-2-ylamine in tetrahydrofuran
T=0°C; Heating / reflux;
参考文献
Array BioPharma Inc.
Patent: US2009/156603 A1, 2009 ;
Location in patent: Page/Page column 118 ;
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water
Suzuki coupling reaction; Heating;
参考文献
Saito, Ryota; Inoue, Chizuru; Katoh, Akira
Heterocycles, 2004 , vol. 63, # 4 p. 759 - 764
反应条件
bis(benzonitrile)palladium(II) dichloride; sodium carbonate; 1,4-di(diphenylphosphino)-butane in ethanol; water; toluene
Suzuki coupling; 7 h; Heating;
参考文献
Adamczyk, Maciej; Akireddy, Srinivasa Rao; Johnson, Donald D.; Mattingly, Phillip G.; Pan, You; Reddy, Rajarathnam E.
Tetrahedron, 2003 , vol. 59, # 41 p. 8129 - 8142
