1-甲基-4-哌啶甲酸乙酯合成路线 （共 22 条）
反应条件
diisobutylaluminium hydride in hexane; water
参考文献
Dynamac Corporaton
Patent: US4757079 A1, 1988 ;
反应条件
hydrogenchloride; water T=100°C; 6 h;
参考文献
F2G LIMITED
Patent: US2011/9390 A1, 2011 ;
Location in patent: Page/Page column 14 ;
参考文献
Rhone-Poulenc Sante
Patent: US5102890 A1, 1992 ;
反应条件
hydrogenchloride; sodium hydroxide in ethanol
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1607088 A1, 2005 ;
Location in patent: Page/Page column 59 ;
反应条件
in tetrahydrofuran; hexane 0.166667 h; Heating;
参考文献
Bunce, Richard A.; Dowdy, Eric D.
Synthetic Communications, 1990 , vol. 20, # 19 p. 3007 - 3014
反应条件
1: 4-methyl-pentan-2-ol; sodium; toluene 2: ethanol View Scheme
参考文献
Feldkamp et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 3831
反应条件
lithium aluminium tetrahydride in diethyl ether T=20°C; 4 h;
参考文献
SYNTARGA B.V.; GEORG-AUGUST-UNIVERSITAet GOeTTINGEN STIFTUNG OeFFENTLICHEN RECHTS (OHNE BEREICH HUMANMEDIZIN)
Patent: WO2007/89149 A2, 2007 ;
Location in patent: Page/Page column 96 ;
反应条件
1: 84 percent / LiAlH4 / diethyl ether / 4 h / 20 °C
2: 83 percent / NaH / dimethylsulfoxide / 3 h / 70 °C
3: 82 percent / H2; HCl / Pd/C / methanol / 1 h / 20 °C / 2999.46 Torr
View Scheme
参考文献
Tietze, Lutz F.; Major, Felix
European Journal of Organic Chemistry, 2006 , # 10 p. 2314 - 2321
反应条件
1: 78 percent / hexane / 0 °C
2: 90 percent / TsOH / toluene; acetonitrile / Heating
View Scheme
参考文献
Birman, Vladimir B.; Chopra, Anu; Ogle, Craig A.
Tetrahedron Letters, 1996 , vol. 37, # 29 p. 5073 - 5076
