5-氯-3-苯基-1,2,4-噻二唑合成路线 （共 9 条）
反应条件
sodium hydroxide in dichloromethane; water T=0 - 20°C; 2 h;
参考文献
Kono, Mitsunori; Matsumoto, Takahiro; Kawamura, Toru; Nishimura, Atsushi; Kiyota, Yoshihiro; Oki, Hideyuki; Miyazaki, Junichi; Igaki, Shigeru; Behnke, Craig A.; Shimojo, Masato; Kori, Masakuni
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 1 p. 28 - 41
参考文献
Goerdeler,J. et al.
Chemische Berichte, 1960 , vol. 93, p. 963 - 974
参考文献
Goerdeler et al.
Chemische Berichte, 1957 , vol. 90, p. 182,186
反应条件
1: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C 2: hydrogenchloride; water / ethyl acetate / 20 °C View Scheme
参考文献
Kono, Mitsunori; Matsumoto, Takahiro; Kawamura, Toru; Nishimura, Atsushi; Kiyota, Yoshihiro; Oki, Hideyuki; Miyazaki, Junichi; Igaki, Shigeru; Behnke, Craig A.; Shimojo, Masato; Kori, Masakuni
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 1 p. 28 - 41
反应条件
in tetrahydrofuran; hexane; water; toluene
参考文献
LILLY INDUSTRIES LIMITED
Patent: EP455356 A1, 1991 ;
反应条件
in dimethyl sulfoxide T=50°C; 264 h;
参考文献
Goerdeler,J.; Heller,K.-H.
Chemische Berichte, 1964 , vol. 97, p. 225 - 237
反应条件
in dimethyl sulfoxide T=50°C; 96 h;
参考文献
Zbirovsky,M. et al.
Collection of Czechoslovak Chemical Communications, 1971 , vol. 36, p. 4091 - 4098
反应条件
1: 1.) 80percent NaH (paraffin emulsion) / 1.) THF, 2.) i-PrOH, 8 h, 60 deg C
2: 60 percent / p-CH3C6H4SO3H / toluene / Heating
View Scheme
参考文献
Goerdeler,J.; Hammen,H.W.
Chemische Berichte, 1964 , vol. 97, p. 1134 - 1146
反应条件
hydrazine hydrate in ethanol
Ambient temperature;
参考文献
Bulka,E. et al.
Chemische Berichte, 1962 , vol. 95, p. 1983 - 1988
