(S)-2-羟基-2-苯基丁酸合成路线 （共 36 条）
反应条件
potassium hydroxide in methanol; water
参考文献
Lynch, Joseph E.; Eliel, Ernest L.
Journal of the American Chemical Society, 1984 , vol. 106, # 10 p. 2943 - 2948
反应条件
1: 73 percent / tetrahydrofuran; diethyl ether / 3 h / -78 °C
2: 73 percent / NCS, AgNO3 / H2O; acetonitrile
3: I2, KOH / 43 °C
4: KOH / methanol; H2O
View Scheme
参考文献
Lynch, Joseph E.; Eliel, Ernest L.
Journal of the American Chemical Society, 1984 , vol. 106, # 10 p. 2943 - 2948
反应条件
1: 73 percent / NCS, AgNO3 / H2O; acetonitrile
2: I2, KOH / 43 °C
3: KOH / methanol; H2O
View Scheme
参考文献
Lynch, Joseph E.; Eliel, Ernest L.
Journal of the American Chemical Society, 1984 , vol. 106, # 10 p. 2943 - 2948
反应条件
1: 100 percent / n-BuLi / tetrahydrofuran; hexane / -78 deg C, 2 h, -25 deg C, overnight
2: 1.) Me2SO, (CF3CO)2O; 2.) Et3N / 1.) CH2Cl2, 1 h; 2.) 0 deg C
3: 54 percent / tetrahydrofuran; diethyl ether / 3 h / -78 °C
4: NCS, AgNO3 / H2O; acetonitrile
5: I2, KOH / 43 °C
6: KOH / methanol; H2O
View Scheme
参考文献
Lynch, Joseph E.; Eliel, Ernest L.
Journal of the American Chemical Society, 1984 , vol. 106, # 10 p. 2943 - 2948
反应条件
1: 54 percent / tetrahydrofuran; diethyl ether / 3 h / -78 °C
2: NCS, AgNO3 / H2O; acetonitrile
3: I2, KOH / 43 °C
4: KOH / methanol; H2O
View Scheme
参考文献
Lynch, Joseph E.; Eliel, Ernest L.
Journal of the American Chemical Society, 1984 , vol. 106, # 10 p. 2943 - 2948
反应条件
1: NCS, AgNO3 / H2O; acetonitrile
2: I2, KOH / 43 °C
3: KOH / methanol; H2O
View Scheme
参考文献
Lynch, Joseph E.; Eliel, Ernest L.
Journal of the American Chemical Society, 1984 , vol. 106, # 10 p. 2943 - 2948
反应条件
potassium hydroxide in methanol; water
Yield given;
参考文献
Lynch, Joseph E.; Eliel, Ernest L.
Journal of the American Chemical Society, 1984 , vol. 106, # 10 p. 2943 - 2948
反应条件
1: 47 percent / DCC, 4-DMAP / CH2Cl2 / 0 °C
2: ZnCl2 / diethyl ether / 3 h / -78 °C
3: KOH / methanol
View Scheme
参考文献
Basavaiah, Deevi; Pandiaraju, Subramanian; Bakthadoss, Manickam; Muthukumaran, Kannan
Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 997 - 1000
反应条件
1.1: p-toluenesulfonic acid / CH2Cl2 / 5 h / 20 °C
1.2: 0.8 g / potassium carbonate / tetrahydrofuran / 24 h / 20 °C
2.1: 96 percent / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C
3.1: 98 percent / tetrahydrofuran / -78 - 20 °C
4.1: silver(I) nitrate; N-chlorosuccinimide / acetonitrile; H2O / 0 - 4 °C
5.1: 53 percent / silver(I) oxide / tetrahydrofuran; H2O / 0.25 h / cooling
View Scheme
参考文献
Perez-Estrada, Salvador; Lagunas-Rivera, Selene; Vargas-Diaz, Maria Elena; Velazquez-Ponce, Pedro; Joseph-Nathan, Pedro; Zepeda, L. Gerardo
Tetrahedron Asymmetry, 2005 , vol. 16, # 10 p. 1837 - 1843
反应条件
1: tetrahydrofuran / -78 - 20 °C
2: 63 percent / silver(I) nitrate; N-chlorosuccinimide / acetonitrile; H2O / 0 - 4 °C
3: 53 percent / silver(I) oxide / tetrahydrofuran; H2O / 0.25 h / cooling
View Scheme
参考文献
Perez-Estrada, Salvador; Lagunas-Rivera, Selene; Vargas-Diaz, Maria Elena; Velazquez-Ponce, Pedro; Joseph-Nathan, Pedro; Zepeda, L. Gerardo
Tetrahedron Asymmetry, 2005 , vol. 16, # 10 p. 1837 - 1843
