(S)-2-羟基-2-苯基丁酸合成路线 （共 36 条）
反应条件
1: 63 percent / silver(I) nitrate; N-chlorosuccinimide / acetonitrile; H2O / 0 - 4 °C
2: 53 percent / silver(I) oxide / tetrahydrofuran; H2O / 0.25 h / cooling
View Scheme
参考文献
Perez-Estrada, Salvador; Lagunas-Rivera, Selene; Vargas-Diaz, Maria Elena; Velazquez-Ponce, Pedro; Joseph-Nathan, Pedro; Zepeda, L. Gerardo
Tetrahedron Asymmetry, 2005 , vol. 16, # 10 p. 1837 - 1843
反应条件
1: 96 percent / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C
2: 98 percent / tetrahydrofuran / -78 - 20 °C
3: silver(I) nitrate; N-chlorosuccinimide / acetonitrile; H2O / 0 - 4 °C
4: 53 percent / silver(I) oxide / tetrahydrofuran; H2O / 0.25 h / cooling
View Scheme
参考文献
Perez-Estrada, Salvador; Lagunas-Rivera, Selene; Vargas-Diaz, Maria Elena; Velazquez-Ponce, Pedro; Joseph-Nathan, Pedro; Zepeda, L. Gerardo
Tetrahedron Asymmetry, 2005 , vol. 16, # 10 p. 1837 - 1843
反应条件
1: 98 percent / tetrahydrofuran / -78 - 20 °C
2: silver(I) nitrate; N-chlorosuccinimide / acetonitrile; H2O / 0 - 4 °C
3: 53 percent / silver(I) oxide / tetrahydrofuran; H2O / 0.25 h / cooling
View Scheme
参考文献
Perez-Estrada, Salvador; Lagunas-Rivera, Selene; Vargas-Diaz, Maria Elena; Velazquez-Ponce, Pedro; Joseph-Nathan, Pedro; Zepeda, L. Gerardo
Tetrahedron Asymmetry, 2005 , vol. 16, # 10 p. 1837 - 1843
反应条件
1: silver(I) nitrate; N-chlorosuccinimide / acetonitrile; H2O / 0 - 4 °C
2: 53 percent / silver(I) oxide / tetrahydrofuran; H2O / 0.25 h / cooling
View Scheme
参考文献
Perez-Estrada, Salvador; Lagunas-Rivera, Selene; Vargas-Diaz, Maria Elena; Velazquez-Ponce, Pedro; Joseph-Nathan, Pedro; Zepeda, L. Gerardo
Tetrahedron Asymmetry, 2005 , vol. 16, # 10 p. 1837 - 1843
反应条件
1: ZnCl2 / diethyl ether / 3 h / -78 °C
2: KOH / methanol
View Scheme
参考文献
Basavaiah, Deevi; Pandiaraju, Subramanian; Bakthadoss, Manickam; Muthukumaran, Kannan
Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 997 - 1000
反应条件
1: 1) ZnCl2; 2) H3O(1+) / 1) diethyl ether
2: OH(1-) / diethyl ether
View Scheme
参考文献
Boireau, G.; Deberly, A.; Abenhaim, D.
Tetrahedron Letters, 1988 , vol. 29, # 18 p. 2175 - 2176
反应条件
1: 77 percent / benzene / Heating; water sep. by a Dean-Stark trap
2: diethyl ether / 5 °C
3: 2percent HCl / ethanol / 4 h / Heating
4: NaClO2, KH2PO4, 2-methyl-2-butene / acetone; H2O / 0.75 h / Ambient temperature
View Scheme
参考文献
He, Xu-Chang; Eliel, Ernest L.
Tetrahedron, 1987 , vol. 43, # 21 p. 4979 - 4988
反应条件
1: diethyl ether / 5 °C
2: 2percent HCl / ethanol / 4 h / Heating
3: NaClO2, KH2PO4, 2-methyl-2-butene / acetone; H2O / 0.75 h / Ambient temperature
View Scheme
参考文献
He, Xu-Chang; Eliel, Ernest L.
Tetrahedron, 1987 , vol. 43, # 21 p. 4979 - 4988
反应条件
1: 2percent HCl / ethanol / 4 h / Heating
2: NaClO2, KH2PO4, 2-methyl-2-butene / acetone; H2O / 0.75 h / Ambient temperature
View Scheme
参考文献
He, Xu-Chang; Eliel, Ernest L.
Tetrahedron, 1987 , vol. 43, # 21 p. 4979 - 4988
反应条件
potassium hydroxide; water in methanol
4 h; Heating; Yield given. Yields of byproduct given;
参考文献
Boireau, G.; Deberly, A.; Abenhaim, D.
Tetrahedron, 1989 , vol. 45, # 18 p. 5837 - 5844
