(S)-2-羟基-2-苯基丁酸合成路线 （共 36 条）
反应条件
potassium hydroxide; water in methanol
Heating; Title compound not separated from byproducts;
参考文献
Loupy, Andre; Monteux, Daphne A
Tetrahedron, 2002 , vol. 58, # 8 p. 1541 - 1549
反应条件
1: diethyl ether / 3 h / -78 °C
2: 2.5N KOH/MeOH / 2 h / Ambient temperature
View Scheme
参考文献
Basavaiah; Bharathi; Krishna
Synthetic Communications, 1992 , vol. 22, # 6 p. 941 - 947
反应条件
sodium hydroxide
1.) reflux, 2 h, 2.) RT, overnight;
参考文献
Brouillette; Grunewald; Brown; DeLorey; Akhtar; Liang
Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1577 - 1580
反应条件
potassium hydroxide in tetrahydrofuran; methanol
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Huang, Deeng-Lih; Draper, Richard W.
Tetrahedron Letters, 1994 , vol. 35, # 5 p. 661 - 662
反应条件
potassium hydroxide in tetrahydrofuran; methanol
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Huang, Deeng-Lih; Draper, Richard W.
Tetrahedron Letters, 1994 , vol. 35, # 5 p. 661 - 662
反应条件
threo-2,3-dimethoxy-butane
partielle asymmetrische Synthese;
参考文献
Cohen; Wright
Journal of Organic Chemistry, 1953 , vol. 18, p. 432,444
反应条件
potassium hydroxide
1.) ether, -78 deg C, 3 h then r.t., 1 h, 2.) methanol, r.t., 2 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Basavaiah, Deevi; Krishna, Peddinti Rama
Tetrahedron, 1995 , vol. 51, # 44 p. 12169 - 12178
反应条件
diethyl ether
Verseifen des Reaktionsprodukts mit alkoh. Kalilauge;
参考文献
McKenzie; Mitchell
Biochemische Zeitschrift, 1929 , vol. 208, p. 466,469
Biochemische Zeitschrift, 1930 , vol. 224, p. 245
反应条件
(i), (ii) <Et3O>BF4, (iii) aq. KOH; Multistep reaction;
参考文献
Meyers,A.I. et al.
Journal of Organic Chemistry, 1979 , vol. 44, # 13 p. 2247 - 2249
反应条件
1.) hexane/ether, -50°C, 4h; 2.) room temp., 16h, hydrolysis; Yield given. Multistep reaction;
参考文献
Deberly, A.; Boireau, G.; Abenhaim, D.
Tetrahedron Letters, 1984 , vol. 25, # 6 p. 655 - 658
