(5-甲氧基-1H-吲哚-3-基)(氧代)乙酰氯合成路线 （共 12 条）
反应条件
1: NH3 / dioxane / 8 h / 20 °C 2: lithium aluminum hydride / tetrahydrofuran / 8 h / Heating View Scheme
参考文献
Organic Letters, , vol. 4, # 23 p. 4033 - 4035
反应条件
1: triethylamine / tetrahydrofuran / 4 h / 20 °C 2: 94 percent / NaH2PO2*H2O / palladium on activated charcoal / dioxane; H2O / 48 h / 20 °C 3: 100 percent / KOH / tetrahydrofuran; H2O / 20 °C View Scheme
参考文献
Kai, Kenji; Horita, Junko; Wakasa, Kyo; Miyagawa, Hisashi
Phytochemistry, 2007 , vol. 68, # 12 p. 1651 - 1663
反应条件
1.1: triethylamine / 1 h / 0 - 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 - 65 °C 3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 20 °C 4.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C 4.2: 18 h / 20 °C View Scheme
参考文献
ACTELION PHARMACEUTICALS LTD; BOLLI, Martin; BOSS, Christoph; BROTSCHI, Christine; GUDE, Markus; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi, T.
Patent: WO2012/110986 A1, 2012 ;
WO 2012/110986 A1
反应条件
1: triethylamine / tetrahydrofuran / 4 h / 20 °C 2: 94 percent / NaH2PO2*H2O / palladium on activated charcoal / dioxane; H2O / 48 h / 20 °C View Scheme
参考文献
Kai, Kenji; Horita, Junko; Wakasa, Kyo; Miyagawa, Hisashi
Phytochemistry, 2007 , vol. 68, # 12 p. 1651 - 1663
反应条件
1: triethylamine / 1 h / 0 - 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 - 65 °C View Scheme
参考文献
WO2012/110986 A1, ;
WO 2012/110986 A1
反应条件
1: 0.23 g / H2O / 0.5 h / 0 °C 2: 79 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Journal of medicinal chemistry, , vol. 47, # 22 p. 5451 - 5466
反应条件
triethylamine T=0 - 20°C; 1 h;
参考文献
Wang, Hui; Zhu, Ting-Shun; Xu, Ming-Hua
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 46 p. 9158 - 9164,7
Title/Abstract Full Text Show Details
Wang, Hui; Zhu, Ting-Shun; Xu, Ming-Hua
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 46 p. 9158 - 9164
反应条件
triethylamine in tetrahydrofuran
T=20°C; 4 h;
参考文献
Han, Long; Liu, Chuan; Zhang, Wei; Shi, Xiao-Xin; You, Shu-Li
Chemical Communications, 2014 , vol. 50, # 10 p. 1231 - 1233
参考文献
Ye, Qing; Li, Meng; Zhou, Yubo; Pang, Tao; Xu, Lei; Cao, Jiayi; Han, Liang; Li, Yujin; Wang, Weisi; Gao, Jianrong; Li, Jia
Molecules, 2013 , vol. 18, # 5 p. 5498 - 5516
反应条件
1: H2O; CHCl3
2: LiAlH4
View Scheme
参考文献
Vermeulen, Erik S.; Schmidt, Anne W.; Sprouse, Jeffrey S.; Wikstroem, Hakan V.; Grol, Cor J.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5365 - 5374
