4-苄氧基-3-甲氧基苯甲醛合成路线 （共 139 条）
反应条件
1.1: potassium tert-butoxide / tetrahydrofuran / 0.5 h / 0 °C
1.2: 78 percent / tetrahydrofuran / 6 h / 20 °C
2.1: 60 percent / aq. HCl / tetrahydrofuran / 3 h / Heating
3.1: lithium diisopropylamide / tetrahydrofuran / 2 h / -80 - 20 °C
3.2: tetrahydrofuran / 5 h / -80 °C
3.3: 85 percent / aq. oxalic acid / tetrahydrofuran / 1.5 h / Heating
4.1: 92 percent / H2 / Pd/C / ethyl acetate / 4 h / 20 °C
View Scheme
参考文献
Tran, Van H.; Kantharaj, Ravi; Roufogalis, Basil D.; Duke, Colin C.
European Journal of Organic Chemistry, 2006 , # 13 p. 2970 - 2976
反应条件
1: 93 percent / diethyl ether; tetrahydrofuran / 1 h / 20 °C
2: 91 percent / NaO-tBu; cyclohexanone / toluene / 0.5 h / Heating
3: 94 percent / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Heating
4: 71 percent / 70percent HNO3; AcOH / 0.5 h / 20 °C
5: 99 percent / AlCl3; pyridine / ethyl acetate / 2 h / Heating
View Scheme
参考文献
Learmonth, David A.; Alves, Paula C.
Synthetic Communications, 2002 , vol. 32, # 4 p. 641 - 649
反应条件
1: 78 percent / HNO3; H2SO4; AcOH / 1 h / 20 °C
2: 59 percent / NH4OAc / 2 h / Heating
3: 31 percent / HCOONH4; formic acid / Pd/C / methanol / 9 h / 20 °C
View Scheme
参考文献
Rogers, C. Bradford; Blum, Charles A.; Murphy, Bryan P.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 941 - 943
反应条件
1: lithium diisopropyl amide / tetrahydrofuran / -78 °C
2: sodium tetrahydroborate / tetrahydrofuran; water
3: palladium on activated charcoal; hydrogen / methanol
4: 4-acetylamino 2,2,6,6-tetramethylpiperidin-N-oxyl; oxygen; nitric acid; hydrogenchloride / water; acetonitrile / 24 h / 45 °C / |High pressure; |Sealed tube
View Scheme
参考文献
Rahimi, Alireza; Azarpira, Ali; Kim, Hoon; Ralph, John; Stahl, Shannon S.
Journal of the American Chemical Society, 2013 , vol. 135, # 17 p. 6415 - 6418
反应条件
1.1: 77.2 percent / NaH / tetrahydrofuran / 0.17 h / 80 °C / microwave conditions
2.1: I2; NaBH4 / tetrahydrofuran
2.2: aq. H2O2; NaOH
View Scheme
参考文献
Su, Na; Wang, Zhen-Jun; Wang, Li-Zhong; Zhang, Xiao; Dong, Wei-Li; Wang, Hong-Xue; Li, Zheng-Ming; Zhao, Wei-Guang
Chemical Biology and Drug Design, 2011 , vol. 78, # 1 p. 101 - 111
参考文献
Barrett,A.G.M. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 652 - 661
反应条件
amberlyst-15
T=110°C; 2 h;
参考文献
Petchmanee, Thaninee; Ploypradith, Poonsakdi; Ruchirawat, Somsak
Journal of Organic Chemistry, 2006 , vol. 71, # 7 p. 2892 - 2895
反应条件
1: NaBH4 / tetrahydrofuran; ethanol / 0 - 20 °C
2: PBr3 / CH2Cl2 / 0 °C
View Scheme
参考文献
Yang, Li-Ming; Lin, Shwu-Jiuan; Yang, Tsang-Hsiung; Lee, Kuo-Hsiung
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 8 p. 941 - 944
反应条件
1: 61.2 g / 35percent hydrogen peroxide/HCOOH / 3 h / 0 °C
2: 57.8 g / 50percent aq. NaOH / methanol / 1.67 h / Heating
View Scheme
参考文献
Schraml, Jan; Kvicalova, Magdalena; Chvalovsky, Vaclav; Elder, Thomas; Brezny, Robert
Magnetic Resonance in Chemistry, 1990 , vol. 28, # 11 p. 973 - 978
反应条件
1: 61.2 g / 35percent hydrogen peroxide/HCOOH / 3 h / 0 °C
2: 57.8 g / 50percent aq. NaOH / methanol / 1.67 h / Heating
3: 61.0 g / phosphorus oxychloride / 6 h / 55 °C
View Scheme
参考文献
Ishii; Ishikawa; Deushi; et al.
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 9 p. 3024 - 3038
