4-苄氧基-3-甲氧基苯甲醛合成路线 （共 139 条）
反应条件
1: 75 percent / NaH / 1,2-dimethoxy-ethane / 24 h / Heating
2: 86 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 18 h / Ambient temperature
View Scheme
参考文献
Sabitha, Gowravaram; Srinivas, Chitti; Reddy, Teega Rammohan; Yadagiri, Kurra; Yadav, Jhillu Singh
Tetrahedron Asymmetry, 2011 , vol. 22, # 24 p. 2124 - 2133
反应条件
toluene-4-sulfonic acid in dichloromethane
参考文献
Inayama,S. et al.
Journal of Medicinal Chemistry, 1976 , vol. 19, p. 433 - 436
反应条件
1: 75 percent / montmorillonite-K10 / diethyl ether / 1 h / 0 °C
2: 40 percent / B2H6*THF
View Scheme
参考文献
Mnatsakanyan,V.A. et al.
Collection of Czechoslovak Chemical Communications, 1977 , vol. 42, p. 1421 - 1430
反应条件
1.1: nitric acid / 2 h / 0 - 20 °C
2.1: potassium permanganate / acetone / 2 h / 30 - 50 °C
3.1: oxalyl dichloride / toluene / 2 h / Reflux
3.2: 2 h
View Scheme
参考文献
HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup
Patent: WO2012/30160 A2, 2012 ;
反应条件
1.1: nitric acid / 2 h / 0 - 20 °C
2.1: potassium permanganate / acetone / 2 h / 30 - 50 °C
3.1: oxalyl dichloride / toluene / 2 h / Reflux
3.2: 2 h
4.1: acetic acid / 0.17 h / 90 °C
4.2: 1 h / Reflux
View Scheme
参考文献
HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup
Patent: WO2012/30160 A2, 2012 ;
反应条件
1: 55 percent / NaH / tetrahydrofuran / 3 h
2: 27 percent / H2 / Pd/C / ethyl acetate / 3 h / 30 °C
View Scheme
参考文献
Hernandez-Romero, Yanet; Rojas, Juana-Isela; Castillo, Rafael; Rojas, Alejandra; Mata, Rachel
Journal of Natural Products, 2004 , vol. 67, # 2 p. 160 - 167
参考文献
Kratzl,K.; Miksche,G.E.
Monatshefte fuer Chemie, 1963 , vol. 94, p. 753 - 760
反应条件
1: water; nitric acid / 0 °C
2: potassium permanganate; aqueous acetone
View Scheme
参考文献
Nair; Robinson
Journal of the Chemical Society, 1932 , p. 1236,1238
反应条件
1: t-BuOK / various solvent(s)
2: H2 / 10percent Pd/C / dimethylformamide / 60 °C / 760 Torr
View Scheme
参考文献
Baeckstroem, Reijo; Honkanen, Erkki; Pippuri, Aino; Kairisalo, Pekka; Pystynen, Jarmo; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 841 - 846
反应条件
1: 90 percent / ammonium acetate / acetic acid / 1.5 h / Heating
2: LiAlH4 / tetrahydrofuran / 3 h / Heating
3: 78 percent / 1 h / Heating
4: BF3*OEt2; BH3*THF / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Schrittwieser, Joerg H.; Resch, Verena; Wallner, Silvia; Lienhart, Wolf-Dieter; Sattler, Johann H.; Resch, Jasmin; MacHeroux, Peter; Kroutil, Wolfgang
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6703 - 6714
