4-苄氧基-3-甲氧基苯甲醛合成路线 （共 139 条）
反应条件
Pd-BaSO4; ethyl acetate Hydrogenation;
参考文献
Freudenberg; Reichert
Chemische Berichte, 1954 , vol. 87, p. 1834,1838
反应条件
ammonium acetate; acetic acid T=90°C; 4 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 15 p. 4862 - 4871
反应条件
1: 71 percent / KOH, tetrabutylammonium bromide / ethanol / 1 h / 0 °C 2: 85 percent / AcONa. Ac2O / 0.08 h / Heating View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 28, # 2.2 p. 280 - 288
Zhurnal Organicheskoi Khimii, , vol. 28, # 2 p. 348 - 358
反应条件
1: 75 percent / NaH / 1,2-dimethoxy-ethane / 24 h / Heating 2: 86 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 18 h / Ambient temperature 3: 76 percent / pyridine / 16 h / 5 °C 4: 86 percent / NaI / acetone / 21 h / Ambient temperature 6: 1.) B(OH)3, H2, 2.) H2 / 1.) Raney Ni, 2.) 10 percent Pd/C / 1.) MeOH-H2O 5-1, 3.5 h, room temp., 2.) MeOH, 40 min, room temp. View Scheme
参考文献
Sabitha, Gowravaram; Srinivas, Chitti; Reddy, Teega Rammohan; Yadagiri, Kurra; Yadav, Jhillu Singh
Tetrahedron Asymmetry, 2011 , vol. 22, # 24 p. 2124 - 2133
反应条件
nitric acid T=0°C; 1 h;
参考文献
Tsai, Shiou-Chuan; Klinman, Judith P.
Bioorganic Chemistry, 2003 , vol. 31, # 2 p. 172 - 190
反应条件
1: 96.6 percent / NaBH4 / methanol / 3 h 2: 93.5 percent / thionyl chloride / diethyl ether / 6 h 3: dimethylformamide / 168 h / Ambient temperature 4: 1.) cobaltous chloride hexahydrate, NaBH4, 2.) 3 N HCl / 1.) MeOH, 20 deg C, 1 h View Scheme
参考文献
Qian, Wangke; Lu, Weijian; Sun, Haifeng; Li, Zeng; Zhu, Liyuan; Zhao, Rui; Zhang, Lei; Zhou, Shengbin; Zhou, Yu; Jiang, Hualiang; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 15 p. 4862 - 4871
反应条件
1: ammonium acetate / ethanol / 5 h / Reflux 2: palladium 10 on activated carbon; hydrogen; acetic acid / 18 h / 20 °C / 37503.8 Torr / Inert atmosphere; Autoclave View Scheme
参考文献
Von Nussbaum, Franz; Rueth, Matthias; Spiteller, Peter; Huebscher-Weissert, Tina; Loebermann, Florian; Polborn, Kurt; Steglich, Wolfgang
European Journal of Organic Chemistry, 2012 , # 2 p. 380 - 390
反应条件
1.1: sodium tetrahydroborate / methanol; dichloromethane / 1 h / 20 °C 2.1: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 0.83 h / 0 °C 3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.25 h / -78 °C / Inert atmosphere 3.2: 22 h / -78 - -50 °C / Inert atmosphere 4.1: palladium 10 on activated carbon; hydrogen / ethyl acetate / 20 °C / 760.05 Torr / Inert atmosphere View Scheme
参考文献
Allais, Florent; Pla, Thomas J. L.; Ducrot, Paul-Henri
Synthesis, 2011 , # 9 art. no. T14311SS, p. 1456 - 1464
反应条件
1: acetic acid; ammonium acetate / 100 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / |Reflux 3: ethanol / 14 h / |Reflux 4: pyridine / dichloromethane / 1.5 h / 0 - 20 °C 5: trichlorophosphate / acetonitrile / 1 h / |Reflux; |Inert atmosphere 6: [[(η6-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine)]Ru]; formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C 7: water; sodium hydroxide / ethanol / 3 h / 20 °C 8: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C 9: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C 10: hydrogenchloride / water; ethanol / 2 h / |Reflux View Scheme
参考文献
Sun, Haifeng; Zhu, Liyuan; Yang, Huicui; Qian, Wangke; Guo, Lin; Zhou, Shengbin; Gao, Bo; Li, Zeng; Zhou, Yu; Jiang, Hualiang; Chen, Kaixian; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 856 - 868
反应条件
1.1: ammonium acetate / acetic acid / 5 h / Reflux 2.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux 3.1: triethylamine / dichloromethane / 3 h / 20 °C 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux 5.1: sodium hydroxide / chloroform / 0 - 20 °C 6.1: trichlorophosphate / acetonitrile / 3 h / Reflux; Inert atmosphere 6.2: 20 °C / Inert atmosphere; Cooling with ice 7.1: palladium 10 on activated carbon; hydrogen; acetic acid / methanol / 16 h 8.1: berberine bridge enzyme; tris(hydroxymethyl)methylamine hydrochloride; magnesium chloride / toluene / 24 h / 40 °C / pH 9 / Darkness; Enzymatic reaction View Scheme
参考文献
Schrittwieser, Joerg H.; Resch, Verena; Wallner, Silvia; Lienhart, Wolf-Dieter; Sattler, Johann H.; Resch, Jasmin; MacHeroux, Peter; Kroutil, Wolfgang
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6703 - 6714
