4-苄氧基-3-甲氧基苯甲醛合成路线 （共 139 条）
反应条件
1: water; nitric acid / 0 °C 2: concentrated sulfuric acid / 50 - 60 °C 3: aqueous KOH / anschliessend Erwaermen mit Dimethylsulfat View Scheme
参考文献
Nair; Robinson
Journal of the Chemical Society, 1932 , p. 1236,1238
反应条件
1.1: nitric acid / 2 h / 0 - 20 °C 2.1: potassium permanganate / acetone / 2 h / 30 - 50 °C 3.1: oxalyl dichloride / toluene / 2 h / Reflux 3.2: 2 h 4.1: acetic acid / 0.17 h / 90 °C 4.2: 1 h / Reflux 5.1: 1,4-dioxane / 12 h / Reflux 5.2: 3 h / Reflux View Scheme
参考文献
HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup
Patent: WO2012/30160 A2, 2012 ;
反应条件
1: ammonium acetate / acetic acid / 5 h / Inert atmosphere; Reflux 2: lithium aluminium tetrahydride / tetrahydrofuran / 10 °C / Inert atmosphere; Reflux 3: 12 h / Inert atmosphere; Reflux 4: phosphorus pentachloride / chloroform; N,N-dimethyl-formamide / -78 - 20 °C / Inert atmosphere 5: sodium hydroxide / chloroform; water / Inert atmosphere View Scheme
参考文献
Li, Xiaomin; Chen, Zhengping; Tang, Jie; Liu, Chunyi; Zou, Pei; Huang, Hongbo; Tan, Cheng; Yu, Huixin
Archiv der Pharmazie, 2014 , vol. 347, # 5 p. 313 - 319
反应条件
1.1: nitric acid / 2 h / 0 - 20 °C 2.1: potassium permanganate / acetone / 2 h / 30 - 50 °C 3.1: oxalyl dichloride / toluene / 2 h / Reflux 3.2: 2 h 4.1: acetic acid / 0.17 h / 90 °C 4.2: 1 h / Reflux 5.1: 1,4-dioxane / 12 h / Reflux 5.2: 3 h / Reflux 6.1: thionyl chloride; trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 7.1: isopropyl alcohol / 2 h / Reflux 8.1: trifluoroacetic acid / 2 h / Heating View Scheme
参考文献
HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup
Patent: WO2012/30160 A2, 2012 ;
反应条件
pyridinium hydrobromide perbromide in methanol 1.) 0 deg C, 1 h, 2.) r.t., 1 h;
参考文献
Archiv der Pharmazie, , vol. 328, # 4 p. 301 - 305
反应条件
1.1: sodium tetrahydroborate / methanol; dichloromethane / 1 h / 20 °C 2.1: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 0.83 h / 0 °C 3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.25 h / -78 °C / Inert atmosphere 3.2: 22 h / -78 - -50 °C / Inert atmosphere 4.1: palladium 10 on activated carbon; hydrogen / ethyl acetate / 20 °C / 760.05 Torr / Inert atmosphere 5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -15 °C View Scheme
参考文献
Allais, Florent; Pla, Thomas J. L.; Ducrot, Paul-Henri
Synthesis, 2011 , # 9 art. no. T14311SS, p. 1456 - 1464
反应条件
1: 96 percent / AcOH; ethylenediamine / 20 °C 2: 96 percent / LAH / tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Silveira, Claudio C.; Bernardi, Carmem R.; Braga, Antonio L.; Kaufman, Teodoro S.
Tetrahedron Letters, 1999 , vol. 40, # 27 p. 4969 - 4972
反应条件
lithium aluminium tetrahydride; acetic acid 1.) reflux; 2.) THF; Yield given. Multistep reaction;
参考文献
Wiegand; Schafer
Tetrahedron, 1995 , vol. 51, # 18 p. 5341 - 5350
反应条件
sodium in diethyl ether 5.5 h; Heating;
参考文献
Ahvonen, Toivo; Brunow, Goesta; Kristersson, Per; Lundquist, Knut
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1983 , vol. 37, # 9 p. 845 - 850
反应条件
1: 100 percent / NaH / tetrahydrofuran / 1.5 h / 0 °C 2: 75 percent / H2 / 10percent PtO2 / ethanol; CHCl3 / 20 h / 20 °C View Scheme
参考文献
Pouysegu, Laurent; Avellan, Anne-Virginie; Quideau, Stephane
Journal of Organic Chemistry, 2002 , vol. 67, # 10 p. 3425 - 3436
