1: 1-(2,2-diethylbutanoyl)-3-methylindole With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in diethyl ether; hexane; cyclohexane T=-78°C; Metallation; 1 h; 2: N,N-dimethyl-formamide T=-78°C; Formylation; 1 h;

1.1: sec-BuLi; TMEDA / diethyl ether; hexane; cyclohexane / 1 h / -78 °C 1.2: 67 percent / Br2F3CCBrF2 / 1 h / -78 °C 2.1: 85 percent / t-BuOK; H2O / tetrahydrofuran / 2 h / 20 °C View Scheme