10H-吲哚并[3,2-b]喹啉合成路线 （共 69 条）
反应条件
phosphorus trichoride in chloroform
1 h; Heating;
参考文献
Goerlitzer; Ventzke-Neu
Pharmazie, 1997 , vol. 52, # 12 p. 919 - 926
反应条件
pyridine hydrochloride
T=200 - 220°C; Cyclization; 4 h;
参考文献
Csanyi; Timari; Hajos
Synthetic Communications, 1999 , vol. 29, # 22 p. 3959 - 3969
反应条件
1: 94 percent / Pd(PPh3)4; aq.K2CO3 / ethanol; toluene / 48 h / Heating
2: 83 percent / pyridinium chloride / 0.5 h / 215 °C
View Scheme
参考文献
Arzel; Rocca; Grellier; Labaeid; Frappier; Gueritte; Gaspard; Marsais; Godard; Queguiner
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 949 - 960
反应条件
barium dihydroxide; zinc
T=180°C; im Rohr; Erhitzen des Reaktionsprodukts mit Zinkstaub;
参考文献
Schuetzenberger
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1877 , vol. 85, p. 147
Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften, 1877 , p. 511
反应条件
palladium diacetate; trifluoroacetic acid
T=90°C; 0.666667 h;
参考文献
Fan, Pingchen; Ablordeppey, Seth Y.
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 6 p. 1789 - 1794
反应条件
1: 85 percent / caesium carbonate; 9,9-dimethyl-4,5-(diphenylphosphino)-9H-xanthene / Pd2(dba)3 / dioxane / 16 h / Heating
2: NaOAc*3H2O / PdCl2(PPh3)2 / N,N-dimethyl-acetamide / 0.17 h / 180 °C / microwave irradiation
View Scheme
参考文献
Hostyn, Steven; Maes, Bert U.W.; Van Baelen, Gitte; Gulevskaya, Anna; Meyers, Caroline; Smits, Koen
Tetrahedron, 2006 , vol. 62, # 19 p. 4676 - 4684
反应条件
1: 94 percent / Pd(PPh3)4; aq.K2CO3 / ethanol; toluene / 48 h / Heating
2: 83 percent / pyridinium chloride / 0.5 h / 215 °C
View Scheme
参考文献
Arzel; Rocca; Grellier; Labaeid; Frappier; Gueritte; Gaspard; Marsais; Godard; Queguiner
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 949 - 960
反应条件
1: 95 percent / LDA / tetrahydrofuran; hexane / 2 h / -78 °C
2: 94 percent / Pd(PPh3)4; aq.K2CO3 / ethanol; toluene / 48 h / Heating
3: 83 percent / pyridinium chloride / 0.5 h / 215 °C
View Scheme
参考文献
Arzel; Rocca; Grellier; Labaeid; Frappier; Gueritte; Gaspard; Marsais; Godard; Queguiner
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 949 - 960
反应条件
1.1: K2CO3 / dimethylformamide / 0.5 h / 20 °C
1.2: 25 percent / dimethylformamide / 2 h / 20 °C
2.1: NaH / tetrahydrofuran / 1 h / 20 °C
2.2: 77 percent / aq. NaOH / ethanol / 0.5 h / Heating
3.1: 70 percent / PCl5 / 3 h / Heating
4.1: 80 percent / HCl; H2 / 10 percent Pd/C / methanol / 2 h / 760 Torr
View Scheme
参考文献
Radl; Konvicka; Vachal
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 4 p. 855 - 862
反应条件
1: 4 M aq. KOH / a) RT, 5 d, b) 70 deg C, 20 min
2: diphenyl ether / 6 h / 255 °C
View Scheme
参考文献
Bierer, Donald E.; Dubenko, Larisa G.; Zhang, Pingsheng; Lu, Qing; Imbach, Patricia A.; Garofalo, Albert W.; Phuan, Puay-Wah; Fort, Diana M.; Litvak, Joane; Gerber, R. Eric; Sloan, Barbara; Luo, Jian; Cooper, Raymond; Reaven, Gerald M.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 15 p. 2754 - 2764
