10H-吲哚并[3,2-b]喹啉合成路线 （共 69 条）
反应条件
1: 40 percent / BuLi / tetrahydrofuran / -78 °C
2: 88 percent / MnO2 / CH2Cl2 / Ambient temperature
3: 72 percent / hydrogen / Pd-C
4: 87 percent / PhNMe2 / Ambient temperature
5: 80 percent / NaH / tetrahydrofuran / Heating
6: 85 percent / NaOH / methanol / Heating
7: 95 percent / POCl3 / Heating
8: 95 percent / hydrogen / Pd-C / ethanol
View Scheme
参考文献
Cooper; Lovell; Joule
Tetrahedron Letters, 1996 , vol. 37, # 24 p. 4283 - 4286
反应条件
1: 40 percent / BuLi / tetrahydrofuran / -78 °C
2: 88 percent / MnO2 / CH2Cl2 / Ambient temperature
3: 72 percent / hydrogen / Pd-C
4: 87 percent / PhNMe2 / Ambient temperature
5: 80 percent / NaH / tetrahydrofuran / Heating
6: 85 percent / NaOH / methanol / Heating
7: 95 percent / POCl3 / Heating
8: 95 percent / hydrogen / Pd-C / ethanol
View Scheme
参考文献
Cooper; Lovell; Joule
Tetrahedron Letters, 1996 , vol. 37, # 24 p. 4283 - 4286
反应条件
1: 85 percent / NaOH / methanol / Heating
2: 95 percent / POCl3 / Heating
3: 95 percent / hydrogen / Pd-C / ethanol
View Scheme
参考文献
Cooper; Lovell; Joule
Tetrahedron Letters, 1996 , vol. 37, # 24 p. 4283 - 4286
反应条件
1: 80 percent / NaH / tetrahydrofuran / Heating
2: 85 percent / NaOH / methanol / Heating
3: 95 percent / POCl3 / Heating
4: 95 percent / hydrogen / Pd-C / ethanol
View Scheme
参考文献
Cooper; Lovell; Joule
Tetrahedron Letters, 1996 , vol. 37, # 24 p. 4283 - 4286
反应条件
1.1: K2CO3 / dimethylformamide / 0.5 h / 20 °C
1.2: 25 percent / dimethylformamide / 2 h / 20 °C
2.1: NaH / tetrahydrofuran / 1 h / 20 °C
2.2: 77 percent / aq. NaOH / ethanol / 0.5 h / Heating
3.1: 70 percent / PCl5 / 3 h / Heating
4.1: 80 percent / HCl; H2 / 10 percent Pd/C / methanol / 2 h / 760 Torr
View Scheme
参考文献
Radl; Konvicka; Vachal
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 4 p. 855 - 862
反应条件
1.1: NaH / tetrahydrofuran / 1 h / 20 °C
1.2: 77 percent / aq. NaOH / ethanol / 0.5 h / Heating
2.1: 70 percent / PCl5 / 3 h / Heating
3.1: 80 percent / HCl; H2 / 10 percent Pd/C / methanol / 2 h / 760 Torr
View Scheme
参考文献
Radl; Konvicka; Vachal
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 4 p. 855 - 862
反应条件
1.1: NaH / tetrahydrofuran / 1 h / 20 °C
1.2: 90 percent / aq. NaOH / ethanol / 0.5 h / Heating
2.1: 70 percent / PCl5 / 3 h / Heating
3.1: 80 percent / HCl; H2 / 10 percent Pd/C / methanol / 2 h / 760 Torr
View Scheme
参考文献
Radl; Konvicka; Vachal
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 4 p. 855 - 862
反应条件
1.1: K2CO3 / dimethylformamide / 0.5 h / 20 °C
1.2: 40 percent / dimethylformamide / 2 h / 20 °C
2.1: NaH / tetrahydrofuran / 1 h / 20 °C
2.2: 90 percent / aq. NaOH / ethanol / 0.5 h / Heating
3.1: 70 percent / PCl5 / 3 h / Heating
4.1: 80 percent / HCl; H2 / 10 percent Pd/C / methanol / 2 h / 760 Torr
View Scheme
参考文献
Radl; Konvicka; Vachal
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 4 p. 855 - 862
反应条件
triethyl phosphite
4 h; Heating;
参考文献
Dutta, Bishnupada; Some, Surajit; Ray, Jayanta K.
Tetrahedron Letters, 2006 , vol. 47, # 3 p. 377 - 379
反应条件
1.1: toluene-4-sulfonic acid / acetonitrile / 10 - 15 °C / Inert atmosphere
1.2: 1.17 h / 20 °C / Inert atmosphere
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
2.2: 0.5 h / Inert atmosphere
3.1: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / toluene / 0.08 h / 20 °C / Inert atmosphere
3.2: 16 h / 110 °C / Inert atmosphere
4.1: potassium tert-butylate / dimethyl sulfoxide / 0.17 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Letessier, Julien; Detert, Heiner
Synthesis, 2012 , vol. 2012, # 2 p. 290 - 296
