10H-吲哚并[3,2-b]喹啉合成路线 （共 69 条）
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
2: benzoyl chloride; potassium carbonate / dichloromethane; water / 0 - 20 °C
3: phosphorus oxytribromide / toluene / 3 h / 0 °C / |Reflux
4: palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; caesium carbonate / toluene / 1.5 h / 120 °C / |Inert atmosphere; |Microwave irradiation
5: bis-triphenylphosphine-palladium(II) chloride; sodium acetate / N,N-dimethyl acetamide / 1 h / 150 °C / |Inert atmosphere; |Microwave irradiation
View Scheme
参考文献
Boganyi, Borbala; Kaman, Judit
Tetrahedron, 2013 , vol. 69, # 45 p. 9512 - 9519
反应条件
1: benzoyl chloride; potassium carbonate / dichloromethane; water / 0 - 20 °C
2: phosphorus oxytribromide / toluene / 3 h / 0 °C / |Reflux
3: palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; caesium carbonate / toluene / 1.5 h / 120 °C / |Inert atmosphere; |Microwave irradiation
4: bis-triphenylphosphine-palladium(II) chloride; sodium acetate / N,N-dimethyl acetamide / 1 h / 150 °C / |Inert atmosphere; |Microwave irradiation
View Scheme
参考文献
Boganyi, Borbala; Kaman, Judit
Tetrahedron, 2013 , vol. 69, # 45 p. 9512 - 9519
反应条件
1: phosphorus oxytribromide / toluene / 3 h / 0 °C / |Reflux
2: palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; caesium carbonate / toluene / 1.5 h / 120 °C / |Inert atmosphere; |Microwave irradiation
3: bis-triphenylphosphine-palladium(II) chloride; sodium acetate / N,N-dimethyl acetamide / 1 h / 150 °C / |Inert atmosphere; |Microwave irradiation
View Scheme
参考文献
Boganyi, Borbala; Kaman, Judit
Tetrahedron, 2013 , vol. 69, # 45 p. 9512 - 9519
反应条件
T=300°C; Decarboxylation;
参考文献
Yang, Shu-Wei; Abdel-Kader, Maged; Malone, Stan; Werkhoven, Marga C. M.; Wisse, Jan H.; Bursuker, Isia; Neddermann, Kim; Fairchild, Craig; Raventos-Suarez, Carmen; Menendez, Ana T.; Lane, Kate; Kingston, David G. I.
Journal of Natural Products, 1999 , vol. 62, # 7 p. 976 - 983
反应条件
1: 850 mg / aq. KOH / 240 h / 20 °C
2: 300 °C
View Scheme
参考文献
Yang, Shu-Wei; Abdel-Kader, Maged; Malone, Stan; Werkhoven, Marga C. M.; Wisse, Jan H.; Bursuker, Isia; Neddermann, Kim; Fairchild, Craig; Raventos-Suarez, Carmen; Menendez, Ana T.; Lane, Kate; Kingston, David G. I.
Journal of Natural Products, 1999 , vol. 62, # 7 p. 976 - 983
反应条件
in anhydrous xylene
72 h; Reflux;
参考文献
Wentrup, Curt; Lan, Nguyen Mong; Lukosch, Adelheid; Bednarek, Pawel; Kvaskoff, David
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 743 - 753
反应条件
1: polyphosphoric acid / 2 h / 130 °C
2: trichlorophosphate / 2 h / 130 °C
3: palladium 10 on activated carbon; hydrogen; sodium acetate; acetic acid / 2 h / 3102.97 Torr
View Scheme
参考文献
Lavrado, Joao; Cabal, Ghislain G.; Prudencio, Miguel; Mota, Maria M.; Gut, Jiri; Rosenthal, Philip J.; Diaz, Cecilia; Guedes, Rita C.; Dos Santos, Daniel J. V. A.; Bichenkovss, Elena; Douglas, Kenneth T.; Moreira, Rui; Paulo, Alexandra
Journal of Medicinal Chemistry, 2011 , vol. 54, # 3 p. 734 - 750
参考文献
Gellert et al.
Helvetica Chimica Acta, 1951 , vol. 34, p. 642,645
参考文献
Noelting; Steuer
Chemische Berichte, 1910 , vol. 43, p. 3512
参考文献
Fichter, Boehringer
Chemische Berichte, 1906 , vol. 39, p. 3932,3937
