2,2,3,3-四甲基环丙烷羧酸酰氯合成路线 （共 11 条）
反应条件
oxalyl dichloride in dichloromethane T=20°C; 0.8 h;
参考文献
Artman, Linda D.; Balandrin, Manuel F.; Moe, Scott T.; Van Wagenen, Bradford C.; Pesyan, Amir
Patent: US2006/25477 A1, 2006 ;
Location in patent: Page/Page column 8 ;
参考文献
FMC Corporation
Patent: US4375476 A1, 1983 ;
反应条件
sodium hydroxide in diethyl ether; n-heptane; water
参考文献
FMC Corporation
Patent: US4322534 A1, 1982 ;
反应条件
NaCN in n-heptane; water
参考文献
Shell Oil Company
Patent: US4123451 A1, 1978 ;
反应条件
pyridine in dichloromethane 0.5 h; Yield given;
参考文献
Wengatz, Ingrid; Stoutamire, Donald W.; Gee, Shirley J.; Hammock, Bruce D.
Journal of Agricultural and Food Chemistry, 1998 , vol. 46, # 6 p. 2211 - 2221
反应条件
sodium hydroxide in diethyl ether; n-heptane; water
参考文献
FMC Corporation
Patent: US4322534 A1, 1982 ;
反应条件
NaCN in n-heptane; water
参考文献
Shell Oil Company
Patent: US4123451 A1, 1978 ;
反应条件
pyridine in dichloromethane 0.5 h; Yield given;
参考文献
Wengatz, Ingrid; Stoutamire, Donald W.; Gee, Shirley J.; Hammock, Bruce D.
Journal of Agricultural and Food Chemistry, 1998 , vol. 46, # 6 p. 2211 - 2221
反应条件
1: indole With ethylmagnesium bromide in tetrahydrofuran; dichloromethane
T=20°C; 0.25 h;
2: With zinc(II) chloride in tetrahydrofuran; dichloromethane
T=20°C; 0.5 h;
3: 2,2,3,3-tetramethyl-cyclopropane-1-carboxylic acid chloride in tetrahydrofuran; dichloromethane
T=20°C; 6 h;
参考文献
ABBOTT LABORATORIES
Patent: WO2006/69196 A1, 2006 ;
Location in patent: Page/Page column 32 ;
WO 2006/069196 A1
反应条件
ethylmagnesium bromide; zinc(II) chloride
参考文献
Yao; Hsieh; Frost; Fan; Garrison; Daza; Grayson; Zhu; Pai; Chandran; Salyers; Wensink; Honore; Sullivan; Dart; Meyer
British Journal of Pharmacology, 2008 , vol. 153, # 2 p. 390 - 401
