3,4,5-三甲氧基苯胺合成路线 （共 68 条）
反应条件
1.1: hydrogenchloride / diethyl ether 2.1: diethyl ether / 1.5 h / 170 °C 3.1: sodium hydroxide; dihydrogen peroxide / water / 0.67 h / 100 °C 3.2: pH 8 3.3: pH 3 4.1: diethyl ether; methanol / 0.17 h / 25 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; KALLANDER, Lara, S.; LAWHORN, Brian, Griffin; PHILP, Joanne
Patent: WO2011/56740 A1, 2011 ;
WO 2011/056740 A1
反应条件
1: α-phenylbenzeneacetic acid; 4-methyl-benzoic acid With thionyl chloride Combinatorial reaction / High throughput screening (HTS); 2: 2-(4-hydroxyphenyl)ethylamine; 1-adamantaneamine; 2-(4-methylphenyl)-ethylamine; 2-(3,4-dimethoxyphenyl)-ethylamine; phenethylamine; 2-(4-methoxy-phenyl)ethylamine; 3,4,5-trimethoxy-phenylamine; 2-(3-methoxy-phenyl)-ethylamine; 1-amino-2-(2-methoxyphenyl)ethane; (1R*,2S*)-2-methylamino-1-phenyl-1-propanol
参考文献
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Patent: WO2005/44191 A2, 2005 ;
Location in patent: Figure 12 ;
反应条件
T=160°C; 0.0833333 h;
参考文献
Bartolucci; Cellai; Di Filippo; Brizzi; Pellerano; Savini; Benedetto; Elia
Farmaco, 1992 , vol. 47, # 6 p. 945 - 952
反应条件
1: 1.) boron trichloride / 1) 1,2-dichloroethane, ice-cooling; 2) reflux, 3 h 2: sodium borohydride / dioxane; H2O / 1.5 h / Heating View Scheme
参考文献
Hewlins, Michael J. E.; Jackson, Anthony H.; Oliveira-Campos Ana-M.; Shannon, Patrick V. R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 2906 - 2911
反应条件
1: With hydrogenchloride; water; sodium nitrite T=5°C; 2: With potassium iodide in water T=0 - 20°C;
参考文献
Barbosa, Euzebio G.; Bega, Luis A.S.; Beatriz, Adilson; Sarkar, Taradas; Hamel, Ernest; do Amaral, Marcos S.; de Lima, Denis Pires
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 6 p. 2685 - 2688
反应条件
1: With hydrogen bromide; sodium nitrite 0.5 h; 2: With copper(I) bromide in water T=20 - 100°C; Further stages.;
参考文献
Paizs, Csaba; Bartlewski-Hof, Ulrike; Retey, Janos
Chemistry - A European Journal, 2007 , vol. 13, # 10 p. 2805 - 2811
参考文献
U.S. Bioscience, Inc.
Patent: US6017922 A1, 2000 ;
反应条件
hydrogen; acetic acid; nickel monoaluminide in water; ethyl acetate; N,N-dimethyl-formamide
参考文献
FMC Corporation
Patent: US5534518 A1, 1996 ;
反应条件
1: With sulfuric acid; sodium nitrite in water T=10 - 15°C; 2: With sulfuric acid; copper(II) sulfate T=100°C; 2 h;
参考文献
Qin, Qi-Xue; Yang, Jian; Chen, Duo-Zhi; Yang, Bo; Zhang, Ji
Organic Preparations and Procedures International, 2013 , vol. 45, # 4 p. 321 - 324
反应条件
Eintraegen die Diazoniumsalzloesung in siedend heisse 50prozentige Schwefelsaeure;
参考文献
Bignelli
Gazzetta Chimica Italiana, 1897 , vol. 27 II, p. 354
