3,4,5-三甲氧基苯胺合成路线 （共 68 条）
反应条件
1: T=100 - 130°C;
2: With caesium carbonate in 1,4-dioxane
T=100°C;
参考文献
Mahajan, Pankaj S.; Mahajan, Jyoti P.; Mhaske, Santosh B.
Synthetic Communications, 2013 , vol. 43, # 18 p. 2508 - 2516
反应条件
pyridine
Ambient temperature;
参考文献
Rosowsky, Andre; Mota, Clara E.; Queener, Sherry F.
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1959 - 1966
参考文献
Mahajan, Pankaj S.; Mahajan, Jyoti P.; Mhaske, Santosh B.
Synthetic Communications, 2013 , vol. 43, # 18 p. 2508 - 2516
参考文献
Graebe; Suter
Justus Liebigs Annalen der Chemie, 1905 , vol. 340, p. 230
反应条件
1: (i) NaNO2, aq. H2SO4, (ii) aq. KI
2: Cu / 240 °C
View Scheme
参考文献
Erdtman,H. et al.
Acta Chemica Scandinavica (1947-1973), 1963 , vol. 17, p. 1151 - 1156
反应条件
1.1: hydrogenchloride / diethyl ether
2.1: diethyl ether / 1.5 h / 170 °C
3.1: sodium hydroxide; dihydrogen peroxide / water / 0.67 h / 100 °C
3.2: pH 8
3.3: pH 3
4.1: diethyl ether; methanol / 0.17 h / 25 °C
5.1: 2 h / 125 °C
6.1: trichlorophosphate / N,N-dimethyl-formamide / 1 h / 100 °C
View Scheme
参考文献
GLAXOSMITHKLINE LLC; KALLANDER, Lara, S.; LAWHORN, Brian, Griffin; PHILP, Joanne
Patent: WO2011/56740 A1, 2011 ;
WO 2011/056740 A1
反应条件
1: (i) NaNO2, aq. H2SO4, (ii) aq. KI
2: Cu, PhI / 240 °C
View Scheme
参考文献
Erdtman,H. et al.
Acta Chemica Scandinavica (1947-1973), 1963 , vol. 17, p. 1151 - 1156
反应条件
nitric acid in ethanol; water
T=100°C; Inert atmosphere;
参考文献
Yang, Hua-Lin; Fang, Fei; Zhao, Chang-Po; Li, Dong-Dong; Li, Jing-Ran; Sun, Jian; Du, Qian-Ru; Zhu, Hai-Liang
MedChemComm, 2014 , vol. 5, # 2 p. 219 - 225
反应条件
1.1: aq. HBr; NaNO2 / 0.5 h
1.2: 75 percent / CuBr / H2O / 20 - 100 °C
2.1: 41 percent / CuO / various solvent(s) / 63 h / Heating
View Scheme
参考文献
Paizs, Csaba; Bartlewski-Hof, Ulrike; Retey, Janos
Chemistry - A European Journal, 2007 , vol. 13, # 10 p. 2805 - 2811
反应条件
1.1: aq. HBr; NaNO2 / 0.5 h
1.2: 75 percent / CuBr / H2O / 20 - 100 °C
2.1: 48 percent / CuO / various solvent(s) / 63 h / Heating
View Scheme
参考文献
Paizs, Csaba; Bartlewski-Hof, Ulrike; Retey, Janos
Chemistry - A European Journal, 2007 , vol. 13, # 10 p. 2805 - 2811
