3,4,5-三甲氧基苯胺合成路线 （共 68 条）
反应条件
tert.-butylhydroperoxide; 3 A molecular sieve; zirconium tetra-t-butoxide in dichloromethane
3 h; Ambient temperature;
参考文献
Krohn, Karsten; Kuepke, Jochen; Rieger, Hagen
Advanced Synthesis and Catalysis, 1997 , vol. 339, # 4 p. 335 - 339
反应条件
potassium carbonate in sodium hydroxide; ethanol
参考文献
A. H. Robins Company, Incorporated
Patent: US5086055 A1, 1992 ;
反应条件
potassium carbonate in diethylene glycol dimethyl ether; water
参考文献
Nippon Chemiphar Co., Ltd.
Patent: US5070089 A1, 1991 ;
反应条件
sodium carbonate in methanol
参考文献
Otsuka Pharmaceutical Co., Ltd.
Patent: US4734416 A1, 1988 ;
US 4734416 A
反应条件
1.1: copper(I) oxide; copper; potassium carbonate / diethylene glycol dimethyl ether / 5 h / Reflux
2.1: Eaton's reagent / 0.83 h / 80 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere
3.2: 2 h / 20 °C / Inert atmosphere
4.1: hydrogenchloride / ethanol; water / 12 h / Reflux
View Scheme
参考文献
Huang, Pang-Chi; Parthasarathy, Kanniyappan; Cheng, Chien-Hong
Chemistry - A European Journal, 2013 , vol. 19, # 2 p. 460 - 464
反应条件
in toluene
T=100°C; 24 h;
参考文献
Stewart, Andrew O.; Kolasa, Teodozyj
Patent: US2003/232836 A1, 2003 ;
Location in patent: Page 45 ;
US 20030232836 A1
反应条件
1.1: aq. HBr; NaNO2 / 0.5 h
1.2: 75 percent / CuBr / H2O / 20 - 100 °C
2.1: 41 percent / CuO / various solvent(s) / 63 h / Heating
3.1: 58 percent / boron tribromide / CH2Cl2 / 1 h / -80 °C
View Scheme
参考文献
Paizs, Csaba; Bartlewski-Hof, Ulrike; Retey, Janos
Chemistry - A European Journal, 2007 , vol. 13, # 10 p. 2805 - 2811
反应条件
1: 0.95 g / H2SO4; aq. NaNO2; CuSO4*3H2O / 1.25 h / 20 - 60 °C
2: 38 percent / aq. NaOH; TEBA / CHCl3 / 20 h / 70 °C
3: 290 mg / NaOMe / methanol / 3 h / 20 °C
View Scheme
参考文献
Verotta, Luisella; Dell'Agli, Mario; Giolitot, Andrea; Guerrini, Marco; Cabalion, Pierre; Bosisio, Enrica
Journal of Natural Products, 2001 , vol. 64, # 5 p. 603 - 607
