2,6-二溴-4-甲基苯酚合成路线 （共 81 条）
反应条件
sodium hydroxide; N-hexadecyl-N,N,N-trimethylammonium bromide in water T=50°C; 4 h;
参考文献
Tetrahedron, , vol. 43, # 21 p. 5031 - 5038
参考文献
Justus Liebigs Annalen der Chemie, , vol. 425, p. 308
反应条件
nitric acid
T=50°C; 0.0833333 h;
参考文献
Gray, Michael J.; Hartshorn, Michael P.; Penfold, Bruce R.; Vaugnan, John
Australian Journal of Chemistry, 1984 , vol. 37, # 1 p. 55 - 64
反应条件
in diethyl ether
T=37°C; 24 h;
参考文献
Huddle, Penelope A.; Perold, Guido W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2617 - 2625
反应条件
1: pyridine
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / tetrahydrofuran; toluene / 48 h / Inert atmosphere; Reflux
3: water; potassium hydroxide
View Scheme
参考文献
Kimura, Mutsumi; Nomoto, Hirotaka; Masaki, Naruhiko; Mori, Shogo
Angewandte Chemie - International Edition, 2012 , vol. 51, # 18 p. 4371 - 4374
反应条件
1: sodium hydroxide / water; 1,2-dichloro-ethane / 5 h / 30 - 35 °C
2: copper(l) chloride / methanol; N,N-dimethyl-formamide / 8 h / 140 °C / |Autoclave
View Scheme
参考文献
Sankaranarayanan, Ananthakrishnan; Chandalia
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 487 - 492
参考文献
Zlobina,G.A.; Ershov,V.V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1964 , p. 1570 - 1577
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1964 , # 9 p. 1666 - 1675
反应条件
potassium carbonate in acetone
24 h;
参考文献
Cram, D. J.; Dicker, I. B.; Lauer, M.; Knobler, C. B.; Trueblood, K. N.
Journal of the American Chemical Society, 1984 , vol. 106, # 23 p. 7150 - 7167
反应条件
potassium hydroxide; 1-n-butyl-3-methylimidazolium hexafluorophosphate
T=25°C; Williamson synthesis; 2 h;
参考文献
Xu, Zhen Yuan; Xu, Dan Qian; Liu, Bao You
Organic Preparations and Procedures International, 2004 , vol. 36, # 2 p. 156 - 161
反应条件
nitric acid
T=50°C; 0.0833333 h;
参考文献
Gray, Michael J.; Hartshorn, Michael P.; Penfold, Bruce R.; Vaugnan, John
Australian Journal of Chemistry, 1984 , vol. 37, # 1 p. 55 - 64
