1,4-二氢-3(2H)-异喹啉酮合成路线 （共 37 条）
反应条件
(S)-pyrophosphoric acid T=150 - 160°C; 1 h;
参考文献
Kamochi, Yasuko; Watanabe, Yasuo
Heterocycles, 1987 , vol. 26, # 9 p. 2385 - 2391
反应条件
1: 3.25 percent / NaN3 / dimethylformamide / 6 h / 20 °C 2: 48 percent / LiOH / H2O; tetrahydrofuran / 2.5 h / 0 °C 3: 82 percent / DCC; DMAP / CH2Cl2 / 0 - 20 °C 4: H2 / Lindlar catalyst / methanol / 3 h / 20 °C View Scheme
参考文献
Carbohydrate Research, , vol. 337, # 2 p. 87 - 91
反应条件
1: 82 percent / DCC; DMAP / CH2Cl2 / 0 - 20 °C 2: H2 / Lindlar catalyst / methanol / 3 h / 20 °C View Scheme
参考文献
Carbohydrate Research, , vol. 337, # 2 p. 87 - 91
反应条件
1: NBS; benzoyl peroxide / benzene 2: 3.25 percent / NaN3 / dimethylformamide / 6 h / 20 °C 3: 48 percent / LiOH / H2O; tetrahydrofuran / 2.5 h / 0 °C 4: 82 percent / DCC; DMAP / CH2Cl2 / 0 - 20 °C 5: H2 / Lindlar catalyst / methanol / 3 h / 20 °C View Scheme
参考文献
Carbohydrate Research, , vol. 337, # 2 p. 87 - 91
反应条件
1: 48 percent / LiOH / H2O; tetrahydrofuran / 2.5 h / 0 °C 2: 82 percent / DCC; DMAP / CH2Cl2 / 0 - 20 °C 3: H2 / Lindlar catalyst / methanol / 3 h / 20 °C View Scheme
参考文献
Carbohydrate Research, , vol. 337, # 2 p. 87 - 91
反应条件
1: 82 percent / 1.6M n-BuLi / tetrahydrofuran / 0.5 h / -50 °C 2: 43 percent / KNH2 / liquid ammonia; diethyl ether / 1 h / Irradiation View Scheme
参考文献
Journal of the American Chemical Society, , vol. 107, # 2 p. 435 - 443
反应条件
hydrogenchloride in ethanol
参考文献
Clark, Robin D.; Jahangir
Heterocycles, 1991 , vol. 32, # 9 p. 1699 - 1703
反应条件
(S)-pyrophosphoric acid T=200°C; 1 h;
参考文献
Kamochi, Yasuko; Watanabe, Yasuo
Heterocycles, 1987 , vol. 26, # 9 p. 2385 - 2391
反应条件
1: 62 percent / AlCl3 / 1,2-dichloro-benzene / 240 h / 25 °C 2: 67 percent / AlCl3 / cyclohexane / 3 h / 90 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 67, # 25 p. 8943 - 8951
反应条件
1: 87 percent / 3-chlorobenzoperoxoic acid / CH2Cl2 / 1.) 0 deg C, 2.) room temp., 1 h 2: 8 percent / p-toluenesulfonic acid / CCl4 / 0.33 h / Heating 3: 86 percent / Raney nickel / ethanol / 2 h / Heating View Scheme
参考文献
Synthesis, , # 7 p. 534 - 537
